Generic (official
or non
proprietary)
name

Trade
(proprietary)
name

Absorption is defined as the passage of a drug from the site of
administration into the blood stream. Most drugs are absorbed (crosses cell
membrane) by Passive diffusion (along concentration gradient with no carrier

-At acidic pH (stomach) weak acid drugs e.g. Acetyl salicylic acid (Aspirin)
become more unionized\u2192 more lipid soluble\u2192 more absorbable, while weak
basic drug e.g. amphetamine become less unionized (ionized)\u2192 less lipid
soluble\u2192 less absorbable.
-At alkaline pH (Intestine) weak basic drugs become more unionized, more
lipid soluble and more absorbable, while weak acidic drugs become less
unionized, less lipid soluble and less absorbable.

-Absorption from subcutaneous tissue is more rapid than absorption from
mucous membranes EXCEPT pulmonary alveoli.
- Absorption from skeletal muscle is more rapid and complete than from
subcutaneous sites.
2-State of absorbing surface: diarrhea markedly decrease absorption of
systemically acting drugs.
3-State of general circulation: during hypovolemic shock oral and
subcutaneous rout are ineffective and drugs should be given intravenously.

parameter of a drug that
correlates dose with plasma
level.

Vd is not a real volume, small volume indicates extensive plasma protein binding, but large volume indicates extensive tissue binding.