Welcome to Scribd, the world's digital library. Read, publish, and share books and documents. See more
Download
Standard view
Full view
of .
Look up keyword
Like this
2Activity
0 of .
Results for:
No results containing your search query
P. 1
Babesia

Babesia

Ratings: (0)|Views: 300|Likes:
Published by SUTHAN

More info:

Published by: SUTHAN on May 30, 2009
Copyright:Attribution Non-commercial

Availability:

Read on Scribd mobile: iPhone, iPad and Android.
download as DOCX, PDF, TXT or read online from Scribd
See more
See less

02/03/2013

pdf

text

original

 
Babesia
From Wikipedia, the free encyclopedia
Jump to:navigation, search
 
 Babesia
 
Kingdom:EukaryotaPhylum:AlveolataClass:ApicomplexaOrder:AconoidasidaFamily:PiroplasmidaGenus:
Babesiidae
Species
Over 100 species, including:
 Babesia
is a protozoan parasite of the blood that causes a hemolytic disease known asBabesiosis.There are over 100 species of 
 Babesia
identified; however only a handful have beendocumented as pathogenic in humans.
In the United States,
 Babesia microti
is the most common strain associated with humans withother species infecting cattle, livestock and occasionally domestic animals.
People whocontract Babesiosis suffer from malaria-like symptoms. As a result malaria is a commonmisdiagnosis for the disease.
 
Contents
[hide]
[edit] Classification
 Babesia
is a protozoan parasite of which
 Babesia microti
and
 Babesia divergens
are the twospecies to most frequently infect humans. Infections from other species of 
 Babesia
have beendocumented in humans but are not habitually seen. Babesiosis is also known as Piroplasmosis.
Due to historical misclassifications, the protozoa was labeled with many names that are nolonger used. Common names of the disease include Texas Cattle Fever, Redwater Fever, Tick Fever, and Nantucket Fever.
[edit] History
For centuries, Babesiosis was known to be a serious illness for wild and domestic animalsespecially cattle.Victor Babeş,a Romanian scientist who first documented the disease in 1888, described symptoms of a severe hemolytic illness seen uniquely in cattle and sheep.
 Someyears later, Americans Theobald Smith and Fred Kilborne identified the parasite as the cause of Texas Cattle Fever, the same disease described by Babes. Smith and Kilborne also identified thetick as the agent of transmission, a discovery that first introduced the concept of arthropodsfunctioning as disease vectors.
Long believed to be a disease that only affected non-humanmammals, it wasn’t until 1957 that the first case of Babesiosis was seen in humans.
The firstcase was observed in a splenectomized patient as were all people diagnosed up until 1969. Thefirst case of Babesiosis seen in a non-splenectomized patient proved that the protozoan parasitewas pathogenic to all people.
[edit] Clinical presentation
 
The severity of 
 B. microti
infections varies. For 25% of cases in adults and half of cases inchildren, the disease is asymptomatic or mild with flu-like symptoms. In cases of symptomaticinfection, symptoms are characterized by irregular fevers, chills, headaches, general lethargy, pain and malaise.
In severe cases, hemolytic anemia, jaundice, shortness of breath, andhemoglobinuria are documented due to the lytic effects of parasitic multiplication.
Immunocompetent individuals with healthy spleens often recover without treatment.
Splenectomized patients are more susceptible to contracting the disease and the course of infection often ends fatally within 5 to 8 days of symptom onset.
Parasitemia levels can reachup to 85% in patients without spleens compared to 1-10% in individuals with spleens andeffective immune systems. Splenectomized patients suffer from severe hemolytic anemia withoccasional incidences of hepatomegaly and splenomegaly documented.
Complications that arise from
 B. microti
infections include acute respiratory failure, congestiveheart failure, and renal failure. Infections can be fatal in 5-10% of hospitalized patients withincreased risk of death in the immunosupressed, the elderly, and those co-infected with Lymedisease.
 
 B. divergens
infections have a much higher fatality rate (42%) and present with themost severe symptoms. Infected individuals suffer from hemoglobinuria followed by jaundice, a persistently high fever, chills and sweats. If left untreated, B. divergens infections can developinto shock-like symptoms with pulmonary edema and renal failure.
Signs of infection usually arise 1 to 8 weeks after a bite from an infectious tick.
 Infections from
 B. divergens
have a shorter latent period usually ranging from 1-3 weeks.
[edit] Transmission
 Babesia
is spread through the saliva of a tick when it bites. At its nymphal stage, a tick will biteinto the skin for a blood meal. The tick, if not removed, will stay attached for 3 to 6 days withlonger periods of feeding associated with a higher probability of acquiring the parasite. The parasite can survive in the tick as it molts through its various developmental stages resulting inall stages being potentially infectious. Some species of 
 Babesia
can be transmitted from a femaletick to its offspring before migrating to salivary glands for feeding.
B. microti, the mostcommon variety of 
 Babesia
in humans however, has not been shown to transmit transovarialy.
In the Americas,
 Ixodes scapularis
is the most common vector. This hard tick, commonly knownas a deer tick, is also the vector for other tick-associated illnesses such as Lyme disease. Manyspecies of 
 Babesia
only infect non-human mammalian hosts, most commonly cattle, horses, andsheep.
 B. microti
and
 B. divergens
are the two main pathogenic species in humans. Their reservoirs are theorized to be the white-footed mouse (
 Peromuscus leucopus
Rafinesque),microtus voles (
Microtus
spp.), and the white-tailed deer (
Odocoileus virginianus
).
 Thesewoodland species are hypothesized reservoirs because although they are known to harbor thedisease, complete reservoir competence has not yet been shown.
Most cases of transmission between humans are attributed to a tick vector. However, as of 2003the Centers for Disease Control and Prevention (CDC) acknowledged more than 40 cases of Babesiosis contracted from packed red blood cell (PRBC) transfusions and 2 infectionsdocumented from organ transplantation. PRBC transfusions that cause infections were identifiedthrough testing of the blood donor for 
 B. microti
antibodies.
The occurrence of PRBCtransfusions as a mechanism of Babesia transmission puts pressure on governmentalorganizations, such as the CDC, to heighten standard measures for screening blood donations.
[edit] Morphology

Activity (2)

You've already reviewed this. Edit your review.
1 thousand reads
1 hundred reads

You're Reading a Free Preview

Download
scribd
/*********** DO NOT ALTER ANYTHING BELOW THIS LINE ! ************/ var s_code=s.t();if(s_code)document.write(s_code)//-->