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Curs Antiaritmice

Curs Antiaritmice

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Published by Leonard D
Cursul de farmacologie clinica
Spitalul Grigore Alexandrescu
UMF "Carol Davila"
Cursul de farmacologie clinica
Spitalul Grigore Alexandrescu
UMF "Carol Davila"

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Published by: Leonard D on Jun 07, 2009
Copyright:Attribution Non-commercial

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07/12/2013

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ANTIARITMICE
 
 
Clasificarea antiaritmicelor 
Scurteaza potentialulde actiuneBlocheaza canale de Ca
Blocante canale de CaVerpamil, Diltiazem
IVPrelungeste faza 3 derepolarizare> t. repolarizareBlocheaza canale de K
Blocanti canale de KAmiodaronSotalolTonsilat de bretiliu
IIISupreseaza (deprima)faza 4 de depolarizareBlocheaza receptoriibeta1
Beta-blocante adrenergice
-
Atenolol
-
Propranolol
-
Metoprolol
IIIncetineste marcat fazaO de depol.t. repolarizare nmBlocante canale Na+++
FlecainidaPropafenona
I CScurteaza faza 3 derepolarizare< t. repolarizareBlocante canale Na+
LidocainaMexiletinaTocainidaMoricizinaFenitoina
I BIncetineste faza O dedepolarizare> t. repolarizareBlocante canale Na++
ChinidinaProcainamidaDisopiramida
IAClasa I
EfecteelectrofiziologiceMecanism de actiuneClasa (Vaughan- Williams
 
 
Antiaritmice(Therap. Guidelines – cardiovascular 2003 Australia)
Cls.I
 – Compuşi care inhibă canalele rapide de sodiu
Cls. II
– Compuşi care inhibă sistemul simpato-adrenergic
Cls III
– Compuşi care prelungesc potenţialul de acţiune
Cls IV
– Compuşi care inhibă influxul lent de calciuClasa I – se divide în subgrupe corelat cu efectul asupra duratei potenţialului deacţiune
I A
– creşterea duratei P.A
I B
– scăderea duratei P.A.
I C
– fără efecte asupra P.A

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