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Chemintox, Inc.
7325 Bannockburn Ridge CourtBethesda, MD 20817Tel. (301)-320-4506 Fax (301)-320-8258August 27,2003Christie Todd Whitman, AdministratorUS EPA
P.O. Box 1473
Merrifield, VA 22 116
Attn: Chemical Right-to-Know Program
Dear Ms. Whitman:
On behalf of Eastman Chemical Company, I am pleased to submit the Test Plan and
Robust Summaries for the substance designated as “Methyl 4-formylbenzoate” to the
HPV Challenge Program, AR-201. We are submitting the test plan and accompanying
robust summaries directly to EPA to make available to the public. This submission
includes one electronic copy in pdf. format. A hard copy of this submission is available
upon request. The EPA registration number for Eastman Chemical Company is
Please feel free to contact me with any questions or comments you might have
concerning the submission at tadams@therobertsgroup.net, tadams@hemintox.com or
202-33 l-2325.
Sincerely,
Timothy Adams, Ph.D.
Technical Contact Person for Eastman Chemical Company
Test Plan for Methyl 4-formylbenzoateMethyl 4-formylbenzoateCAS No. 001571-08-0Eastman Chemical Company
Submitted to the EPA under the HPV Challenge Program by:Eastman Chemical Company100 North Eastman RoadKingsport, TN 37662Phone: 423-229-5208Fax: 423-224-0208
201-14624A
RECEIVEDOPPT CBIC2003 JUL 28 PM 1:44
TABLE OF CONTENTS
1 IDENTITY OF SUBSTANCES ........................................................................................... 1
2 CHEMICAL ANALYSIS ..................................................................................................... 2
2.1 I
NTRODUCTION
................................................................................................................ 2
2.2 B
ACKGROUND
I
NFORMATION
.......................................................................................... 2
2.3 S
TRUCTURAL
C
LASSIFICATION
........................................................................................ 2
2.4 C
HEMICAL
R
EACTIVITY AND
M
ETABOLISM
.....................................................................4
2.4.1 Hydrolysis of Esters ................................................................................................ 4
2.4.2 Oxidation of the Aldehyde in Methyl 4-formybenzoic Acid .................................... 6
2.4.3 Absorption, Distribution, Metabolism, and Excretion............................................ 9
3 TEST PLAN ........................................................................................................................ 17
3.1 P
HYSICAL AND
C
HEMICAL
P
ROPERTIES
......................................................................... 17
3.1.1 Melting Point......................................................................................................... 17
3.1.2 Boiling Point ......................................................................................................... 17
3.1.3 Vapor Pressure ..................................................................................................... 17
3.1.4 Octanol/Water Partition Coefficients................................................................... 18
3.1.5 Water Solubility..................................................................................................... 18
3.1.6 New Testing Required ........................................................................................... 18
3.2 E
NVIRONMENTAL
F
ATE AND
P
ATHWAYS
....................................................................... 19
3.2.1 Photodegradation.................................................................................................. 19
3.2.2 Stability in Water .................................................................................................. 19
3.2.3 Biodegradation...................................................................................................... 19
3.2.4 Fugacity ................................................................................................................ 20
3.2.5 New Testing Required ........................................................................................... 21
3.3 E
COTOXICITY
................................................................................................................. 21
3.3.1 Acute Toxicity to Fish ........................................................................................... 21
3.3.2 Acute Toxicity to Aquatic Invertebrates................................................................ 22
3.3.3 Acute Toxicity to Aquatic Plants........................................................................... 23
3.3.4 New Testing Required ........................................................................................... 23
3.4 H
UMAN
H
EALTH
D
ATA
.................................................................................................. 25
3.4.1 Acute Toxicity........................................................................................................ 25
3.4.2 Genetic Toxicity.................................................................................................... 25
3.4.3 Repeated Dose Toxicity......................................................................................... 29
3.4.4 Reproductive Toxicity ........................................................................................... 35
3.4.5 Developmental Toxicity......................................................................................... 37
3.4.6 New Testing Required ........................................................................................... 39
3.5 T
EST
P
LAN
T
ABLE
.......................................................................................................... 40
4 REFERENCES FOR TEST PLAN AND ROBUST SUMMARIES .............................. 42
i
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2.4 Fugacity for Environmental Protection Agency: c14624
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