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Autos: 
self
akos 
:relief
“A chemical substance produced by one type of cell that affects the function of different types of cells in the same region”.
1. Eicosanoids: Prostaglandins(PG)Tromboxanes(TX)Leucotrienes(LT)2. Nitricoxide (NO) andplateletactivatingfactor (PAF)3. Polipeptides: AngiotensineandBradykinin.4. Amines: Histamineandserotonin
AUTACOID
Generated“
de novo” 
stored
 
SEROTONINE5-HYDROXITRYPTAMINELocalization: - Enterochromaffin cells (gut) (90%)- platelets- mast cells- brain (1-2%)
 
Synthesis of 5-HT
DietIn enterochromaffincells and neurons
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