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Structural Biology andFunctionsof Immunoglobulin's
Organization and Expression of Immunoglobulin Genes
Kasi.M.KannanLecturer in MicrobiologyV.H.N.S.N.CollegeVirudhunagar
 
Antibodies: Structure andFunction
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Antibodies are the antigen binding proteinspresent on the B-cell membrane and secretedby plasma cells.
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Membrane-bound antibody confers antigenicspecificity on B cells; antigen-specificproliferation of B-cell clones is elicted by theinteraction of membrane antibody withantigen.
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Secreted antibodies circulate in the blood,where they serve as the effectors of humoralimmunity by searching out and neutralizingantigens or marking them for elimination.
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All antibodies share structural features, bindto antigen, and participate in a limited
 
Basic Structure of Antibodies
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 The first evidence that antibodies werecontained in particular serum proteinfractions came from a classic experiment byA. Tiselius and E. A.Kabat, in 1939.
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 They immunized rabbits with the proteinovalbumin (the albumin of egg whites) andthen divided the immunized rabbits’ seruminto two aliquots.
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Electrophoresis of one serum aliquot revealedfour peaks corresponding to albumin and the
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