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on oxidative stressin the liver of young and aged rats
R. Mahesh and V. Hazeena Begum
Department of Siddha Medicine, Faculty of ScienceTamil University, Vakaiyur, Thanjavur - 613 005Tamilnadu, India
Free radical damage has been postulated to play a role in thechanges that occur both during the normal aging process and related degenerative diseases. Increased free radical productionleads to devastation of normal cell functions. The present studywas aimed to evaluate the effect of Terminalia chebula on normal age-related changes. In the liver of aged rats, an increased level of oxidation products and decreased enzymatic, and non-enzymatic antioxidants were noted. However, their levels werereverted to normal after administration of Terminalia chebulaextract at the dose rate of 200 mg/kg body weight for 4 weeks.The present result shows that the administration of Terminalia chebulaacts as a free radical scavenger with potential antioxidant effectsin the liver of aged rats.
Key words :
Aging, Antioxidant enzymes, Liver, Oxidative stress,
.Aging has been defined as the changes that occur in livingorganisms with the passage of time that lead to functional impairmentand ultimately to death. Aging is usually associated with increasinglevels of oxidation and it has been suggested that senescence mayresult from the accumulation of unrepaired structural damage to cells,which disrupts the cellular functions when the organism enters intocontact with different endogenous and exogenous agents. Reactive
Age-related Changes in Lipid Peroxidation
Indian Journal of Gerontology
2007, Vol. 21, No. 2. pp 244-256