BIO 114: BIOLOGY OF NONINFECTIOUS DISEASE — LABORATORY MANUALEXERCISE 5: EFFECT OF ULTRAVIOLET RADIATION ON BACTERIAabsolutely dependent (without nutritional supplementation) on a minimal level of expo-sure to UV light for the production of “vitamin” D.
Thus people are caught between arock and a hard place with regard to UV exposure. Too little is bad; too much is bad.
Skin cancer is currently the most common form of cancer among humans.Different people have different levels of skin pigmentation (higher levels absorb moreharmful UV radiation) and have varying abilities at DNA repair. If you consistentlysustain sunburns outdoors, you have problems, for one reason or another. Althoughthe spread of melanocytes (pigment cells) is inducible by UV radiation, if you haven't gotany to induce, no amount of exposure is going to induce them. Similarly, if your thyminedimer repair mechanisms are poor, no amount of exposure is going to improve theirperformance. One of the case studies we have read describes children with
; patients with this disease are quite defective in thyminedimer repair and thus are very prone to skin cancer.
Keep all this in mind today as youdon protective clothing when working with the UV light. Also keep this in mind the nexttime you bake at the beach.Today you will be given two strains of
, labeled W1485 andVT1306. One of these is wild-type with regard to DNA repair, and one of these isdefective for DNA repair. You will try to identify the unknowns by their relative suscepti-bility to UV light.
(6): 77–91, December 1970.
This discussion has ignored the important issue of sexual selection. Do men at the beach really preferwomen with tans? Do women at the beach really prefer men with tans? Do pale-faced people havefewer descendants? These questions seem silly, but sexual selection seems to push many species inodd directions. Behold the peacock.
. Hiding from the light.
(19): 50–57, 1990.
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