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Kidney disease usually cannot be cured. When the kidneys are damaged, they cannot be repaired. Treatment focuses on slowing the disease and preventing complications. One complication is high blood pressure, also called hypertension. Hypertension damages the kidneys. Two types of blood pressure medicines called angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) protect kidney function. These medicines not only lower blood pressure but also decrease the loss of protein into the urine. Because of this effect, they are often used in IgA nephropathy to protect the kidneys. They are good medicines but have certain side effects. Pregnant women should not take ACE inhibitors or ARBs because they can damage the unborn baby. People with IgA nephropathy may develop high cholesterol. By watching their diet and taking medicine, they can help lower their cholesterol level. Lowering cholesterol may help slow kidney damage. Medicines such as prednisone may help treat IgA nephropathy. Prednisone belongs to a class of medicines called corticosteroids, which can have harmful side effects. In research studies, fish oil supplements containing omega 3 fatty acids also slowed kidney damage in some patients. Vitamin E may help lower protein in the urine but not blood. One of the newer immunosuppressive agents called mycophenolate mofetil (MMF) is also being tested in treating IgA nephropathy.
Take steps to reduce your blood pressure. Keeping your blood pressure levels near normal may help slow kidney damage from IgA nephropathy. Your doctor may recommend healthy changes in your diet including limiting your salt intake losing excess weight, being physically active, using alcohol in moderation and remembering to take your blood pressure medications as ways to keep your blood pressure under control. Monitor your blood pressure levels at home. Note each reading and bring this record with you to your doctor's appointments. Eat less protein. Reducing the amount of protein you eat and taking steps to decrease your cholesterol levels may help slow the progression of IgA nephropathy and protect your kidneys.
Low antigen diet A low antigen diet consists of avoiding gluten, dairy products, eggs, and most meats [141]. The rationale for this regimen is that dietary macromolecules may be responsible for activating the mucosal IgA system. When given to 21 consecutive patients with IgA nephropathy, protein excretion was markedly reduced or fell into the normal range in 11 of the 12 patients whose baseline rate was more than 1 g/day. In addition, repeat renal biopsy showed significant reductions in mesangial IgA and complement deposition and mesangial cellularity. IgA is an autoimmune disease. This is a disease in which a persons own immune system damages their own body. Scientists know that the IgA immune complex causes the inappropriate immune response. But it is not yet known what causes the defective IgA in the first place. It likely has both genetic and environmental components. A person is born with a predisposition for the disease, and then some sort of trigger, for example an infection or food exposure, turns the disease on