INFEKSI VIRUS MULTI-SISTEM

Riyani Wikaningrum Bag. Mikrobiologi Fakultas Kedokteran Univ. Yarsi

Penyakit Infeksi berdasar Sistem

Infeksi Multi-sistem
Vector-borne Zoonosis Fever of Unknown Origin (FUO) Infection of the compromised host

Vector Borne Disease

Arboviruses are arthropod-borne viruses Arbovirus replicate in:
Vascular endothelium CNS Skin and Muscle

Arbovirus infection:
Yellow fever Dengue fever Arbovirus encephalitis Arbovirus and hemorrhagic fever

Yellow Fever
Yellow fever virus is transmitted by mosquitoes and is restricted to Africa, Central and South America and the Caribbean Clinical features of yellow fever may be mild, but liver damage can prove fatal The diagnosis is usually clinical, there is no specific treatment, but there is a vaccine

Dengue Fever
Dengue virus is transmitted by mosquitoes and occurs in southeast Asia, the Pacific area, India and the Caribbean Dengue fever may be complicated by dengue hemorrhagic fever shock syndrome There is no antiviral therapy or vaccine for dengue fever

Arbovirus Enchephalitis
The encephalitic arboviruses only occasionally cause encephalitis

Arboviruses and hemorrhagic fevers

Zoonosis
Some multisystem infections in man are animal diseases (i.e. zoonoses) Viral Haemorrhagic Fever caused by:
Arenaviruses Filoviruses Bunyaviruses Flaviviruses

ARENAVIRUS INFECTIONS
Arenaviruses are transmitted to humans in rodent excreta Arenavirus infection is diagnosed by serology, virus isolation or viral genome detection Lymphocytic choriomeningitis virus occurs worldwide Lassa fever virus is an arenavirus that infects a bush rat in parts of west Africa

KOREAN HEMORRHAGIC FEVER

The Hantaan virus causes Korean hemorrhagic fever and infects rodents

MARBURG AND EBOLA HEMORRHAGIC FEVERS

Viral Multi-System Infection Mucocutaneous Lessions

Patogenesis
Infeksi HSV & VZV

Manifestasi Infeksi HSV

Manifestasi Infeksi VZV

SMALLPOX atau VARIOLA

MORBILLI atau MEASLES (RUBEOLA)

Kopliks spots

MORBILLI atau MEASLES (RUBEOLA)

Measles outbreaks occur every few years in unvaccinated populations Clinical features of measles include respiratory symptoms, Koplik's spots and a rash Measles rash results from a cell-mediated immune response Complications of measles are particularly likely among children in developing countries Measles is usually diagnosed clinically; there is no antiviral treatment, but there is a vaccine

RUBELLA (GERMAN MEASLES)

Rubella virus infection causes a multisystem infection, but its main impact is on the fetus Rubella is diagnosed serologically; there is no treatment, but there is a vaccine