Methyl Salicylate Liniment (BP99) Defn: MS is a cutaneous emulsion.

It conatins 25% v/v of MS in arachis oil or other suitable fixed oils. The liniment complies with the requirements stated under liquids for cutaneous application and with the following requirements: Content of MS: C8H8O3 23.0-26.5 %v/v Characreristics : The liniment ha s acharacteristic odour. In the assay, the chromatogram obtained with solution (2) shows a peak with the same retention time as that due to MS in the chromatogram obtained with (1) Assay : Carry out the method for gas chromatography, appendix IIIB, using 3 solutions in petroleum spirit (boiling range 80-100C) containing (1) 1% W/v of benzoyl alocohol(internal std) and 1% w/v of methyl salicylate (2) 4% w/v of the liniment and (3) 4% w/v of the liniment and 1% w/v of the internal std The chromatographic procedure may be carried out using a glass column (1.5cm x 4mm) packe dwith diatomaceous support (60-80 mesh) coated with 10% w/w polyethylene glycol 1540 and maintained at 110C Det the weight per ml of the liniment, appendix VG and calculate the content of C8H8o3, vol in vol taking the content of C8H8O3 in MS to be 100% and its weight per ml to be 1.18g Label : cutaneous emulsion Pg 2236