Spironolactone 25 mg, Butizide 2.5 mg
Essential hypertension, edema and ascites of CHF, liver cirrhosis, nephriticsyndrome, idiopathic edema
Mechanism of Action:
: competes with aldosterone for receptor sites in the distal renaltubules, increasing sodium chloride and water excretion while conserving potassium and hydrogen ions, may block the effect of aldosterone on arteriolar smooth muscle as well
Essential Hypertension 2-4 tab/day for 2 weeks or longer. Edema initially 4 tabdaily then reduce to optimum dose. If adequate diuretic does not occur after 3days, increase dose up to 8 tab daily. Children 1.65-3.3 mg of spironolactone/kg/day in divided doses
Acute or severe hepatic failure decompensated hepatic cirrhosis, pregnancy, lactation, concominant administration of K supplements or other K sparing agents, SLE. Monitor fluid and electrolytes.
Pregnancy Risk Category D