Brand name:

CiprobayGeneric name:

Ciprofloxacin

Drug Classification:

Antibiotics (Quinolones)

Indications:

Infections of the respiratory tract, middle ear, sinuses, eyes, kidneys and urinary tract,genital organs, abdomen, skin and soft tissues, bones and joints; further, septicemia,infections in patients with reduced host defense and for selective intestinaldecontamination in immuno suppressed patients.

Mechanism of action:

Inhibits DNA-gyrase in susceptible organism; inhibits relaxation of supercoiled DNA and promotes breakage of double-stranded DNA.

Dose:

Tab 125-750 mg orally bid. Respiratory tract infections 500 mg bid. Acute gonorrhea 250mg orally as single dose. The normal dose must be reduced if creatinine clearance is <20 ml/min. 500 XR tab acute uncomplicated UTI (acute cystitis) 1 tab/day for 3 days IVinfusion 100-200 mg bid. Resp tract infections 200-400 mg bid. Acute, uncomplicatedUTI and extra genital gonorrhea 100 mg bid. Pre-menopausal cystitis and acute,uncomplicated gonorrhea single dose 100 mg. Complicated cystitis and diarrhea 200 mg bid. Severe infections 400 mg tid.

Contraindication:

hypersensitivity to ciprofloxacin or other quinolones. Children, adolescents, pregnancy and lactation.

Special Precautions:

Epilepsy, CNS damage. Photosensitivity. May affect ability to drive or operate machinery.