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Pharmacodynamics
 
Protein Receptors
Receptors for endogenous regulatoryligands – hormones, growth factors,neurotransmit-ters;
Enzymes of crucial metabolic orregulatory pathways –Acetylcholinesterase,
Enzymes in transport processes –Na/K pump;
Structural proteins – Tubulin;
 
Drug – Receptor Interactions
Receptor– specific macromolecule( Proteins – 90% - membrane, cytoplasmicor extracellular enzyme, nucleic acid;Lipids; Carbohydrates) which is the site of action of most drugs: Only around 10% of drug actions & effects are NOT mediatedthru receptors.
For most drugs, the magnitude of thepharmacological response increases as thedose (drug concentration) increases
Only one drug molecule occupies eachreceptor site, & binding is reversible
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