TRANSDERMAL DRUG DELIVERY SYSTEM
drugs across this layer. The method to circumvent this is to engineer the drugs be both water-soluble and lipid soluble. The best mixture isabout fifty percent of the drug being each. This is because “Lipid-solublesubstances readily pass through the intercellular lipid bi-layers of the cellmembranes whereas water-soluble drugs are able to pass through the skin because of hydrated intracellular proteins”. Using drugs engineered in this manner, much morerapid and useful drug delivery is possible.( the stratum corneum develops a thin, tough,relatively impermeable membrane which usually provides the rate limiting step intransdermal drug delivery system. Sweat ducts and hair follicles are also paths of entry, but they are considered rather insignificant.
Types of TDS
Liquid Reservoir PatchDrug in solution or suspension between the backing layer and a ratecontrolling membrane
Drug in Adhesive PatchDrug dispersed in adhesive, in direct contact with skin
Polymer Matrix PatchDrug in solution or suspension dispersed within a polymer
Multi-laminate Matrix PatchDrug dispersed in adhesive in multi-layers separated by membranes.
TYPES OF TRANSDERMAL PATCHESFour Major Transdermal Systems1. Single-layer Drug-in-Adhesive
RKDF COLLEGE OF PHARMACYPage