WFI by Microwave Continuous Process
By William Greco page 1 of 5July 2009Warrington, Pa.email@example.com
The most widely used raw material in the Pharmaceutical Industry is water.Water used for the manufacture of cell culture medium and cleaning of equipment istermed USP (United States Pharmacopedia) WFI (water for injection).The grade of water most difficult and most expensive to produce is WFI.WFI is commonly produced by distillation or reverse osmosis. Many WFI systemsutilize carbon filtration and deionization for pre-treatment before distillation.The water must then be recycled in a hot, closed loop system and stored in tanksat a high temperature to prevent microbial growth.
Microwave WFI systems are being developed to provide energy efficient means of providing medical grade water that can be used in a continuous process.
Advantages of Microwave WFI Systems
The substantial aspect of a microwave WFI system is the ability to thermallydeactivate endotoxins in a continuous process, which eliminates expensive systemelements such as
-filtration membranes, stainless steel piping loops and storagetanks, at the same time saving energy. On demand WFI by continuous process has theadvantage of being more pure than WFI stored over a period of time in tanks.These characteristics have the following applications :
In a range of large systems that meet various requirementsT
o select and protect by sterilization vulnerable connections to WFI water productionTo save energy in the production of WFILightweight and portable Microwave Powered Continuous Flow WFI equipment can berapidly deployed during emergencies (when the main system is off-line).