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Table Of Contents

1.2 ATP- and Substrate-Binding Sites
1.3 Substrate Recognition
2. Polymorphisms of P-Glycoprotein
3. In Vitro/In Vivo Extrapolation and Species Differences
4. Role of P-Glycoprotein in Pharmacokinetics
4.1 Drug Absorption
4.1.1 Distribution of Intestinal P-Glycoprotein
4.1.2 Interindividual Variability of Intestinal P-Glycoprotein
4.1.3 Evidence of Intestinal P-Glycoprotein Involvement in Drug Absorption
4.2 Drug Distribution
4.2.1 Blood-Brain Barrier
4.2.2 Placenta
4.3 Drug Metabolism
4.4 Drug Excretion
4.4.1 Biliary Excretion
4.4.2 Renal Excretion
5. P-Glycoprotein-Mediated Drug-Drug Interactions
5.1 P-Glycoprotein Inhibition Does Not Follow Simple Kinetics
5.2 Drug Interactions Caused by P-Glycoprotein Inhibition
5.3 P-Glycoprotein Induction is a Complex Process
5.4 Drug Interactions Caused by P-Glycoprotein Induction
6. Conclusions
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p glco prot

p glco prot

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Published by Doyin Awodele
p glyco
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Published by: Doyin Awodele on Oct 06, 2013
Copyright:Attribution Non-commercial


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