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NRDC comments to BOSC Feb051
NRDC Comments to BOSCon the Use of Default Assumptions andUncertainty Factors in EPA Risk AssessmentsFebruary 2, 2005
Jennifer Sass, Ph.D.Senior scientist, Health and EnvironmentNatural Resources Defense CouncilWashington, DC, 20005tel: 202-289-2362, fax: 202-289-1060, email: jsass@nrdc.org
 
NRDC comments to BOSC Feb052
•finalize the 2003 Draft Cancer Guidelines andSupplemental•expand default assumption of susceptibility of early life-stages for mutagenic carcinogens, toalso include non-mutagenic carcinogens•provide clarity on what constitutes “adequate”data to depart from default assumptions of linearity at low doses of mutagenic carcinogens
 
NRDC comments to BOSC Feb053
•require consistently rigorous consideration of allplausible modes of action, consideration of alternate pharmacokinetic models, and fullconsideration of the effects on all life stages andsensitive populations when departing fromdefault uncertainty factors•require consistent application of defaultassumptions, particularly where critical data arelacking
 
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