Determination of the Base Concentration of Antacidsand their Neutralizing Power
Dutong, Faye, Feliciano, Felimon Jr., Gorospe, Tryxia Althea Jenn A., Guzon, Abegail
Department of Biology, College of Science, University of the Philippines BaguioOctober 3, 2013
Antacids serve as stomach pains reliever specifically hyperacidity. They contain a basiccomponent that usually reacts with the HCl found in the stomach. This study was undertaken to developa clear description of Mg(OH)
content of antacid brands and the HCl concentration neutralized by thebasic compound. The said brands are Maalox, Kremil-S, and Geltazine. The used method for theexperiment involves the back-titration where in an excess of solvents accustomed in dissolving theantacid samples. It was found that the least reactive among the three chosen brands is the Geltazineand the strongest one came from the Kremil S which has a neutralizing power of 0.04608 moles HCl pergram of antacid. In conclusion, it is best to use Kremil S when experiencing severe hyperacidity.
Many experience gas pains or stomachaches due to excessive gastric acidity. In orderto reduce the pain felt , one may take antacidmedicines which normally react with theHydrochloric acid present in the stomach. Theinner substance of the stomach will then beneutralized after some time after taking theantacid tablet. The major component existing inmany antacids that reacts with the acid isusually Magnesium Hydroxide (MgOH
) butother components are also expected to bepresent. The creation of the antacids wasindeed another improvement to human life. Itdoes not only reduce provisional pains instomach but it also prevents long-term stomachdiseases or disorders like the disintegration of the gastric lining that may lead to successivedisorders or even worst to death. So, one mayconclude that antacids mainly function inrelieving indigestion and heartburn.The aim of the study is to determine theconcentration of HCl neutralized by the antacidsamples and of course the mass of Mg(OH)
present in the various antacids. Three differentbrands of antacids are taken as samplesMaalox, Kremil-S, and Geltazine () and theintention is to know which among the three hasthe highest or lowest capability of neutralizinghyperacidity in stomach. Thus the study offers arapid and ideal conception on to which antacidis better to take when experiencing mild,moderate, or severe stomach pains due toexcessive acid.
METHODOLOGYStandardization of NaOH solution
We began this experiment by weighingapproximately 0.1g of NaOH pellets. We thenlaced it into a volumetric flask, added a bit of distilled water, stirred it untilit dissolved thendiluted it up to the mark. Next,we washed thebase burette with a little amount of theprepared sodium hydroxide solution and filledthis up with the same solution. We weighedapproximately 0.3 g of KHP into a clean flaskand dissolved it with 50mL of distilled water.