Pathophysiology of Uterine MyomaUterus
Etiology:Predisposing Factors:- Unknown- Advancing Age- Genetics- Race- StressPrecipitating Factors:- Over Weight
Disease Process
- Hyperestrogenic State- Hypertension- Nulliparity- Multiparity- Menopause- Contraceptives- Smoking
Benign tumors originating in the smooth muscular uterine tissue, though sometimes theyoriginate in the smooth muscle of the uterine vesselsStress within the myometrium
(Due to physical and mental means resulting from uterine contractions.Multiple fibroids)
Simple proliferation (monoclonal) of smooth muscle cells
(Continuous development of group of cells from a single ancestral cell by repeated cellular replication; cell formation)
Development of Leiomyomas ( fibroid )Fibroid Growth Increase
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Estrogen-dependent tumors, their growth is related to their exposure to circulatingestrogens
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Express maximal growth during the generativeage of a female, when estrogen secretion isat its highest, and growth curve is especially slope in the decade preceding menopause(probably as the consequence of anovulatory cycles with unopposed circulatory estrogen)
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sometimes grow during pregnancy, which is probably related to estrogen, as well as anincreased blood flow in pregnancy and edema. Estrogen receptors are present in a higher concentration within myomas than in the adjacent myometrium.
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Hormonal therapy
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tnx
tnx
MYOMA UTERI A&P
nice..
where are the arrows? hehe ^_^
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...CAN'T YOU POST A MORE DETAILED PATHOPHYSIOLOGY WITH ITS DIAGRAM?...
it depends on how you understand its pathophysiology and fyi this is more understood patho. Godbless