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Penicillins inhibit a bacterial enzyme called the transpeptidasePenicillins inhibit a bacterial enzyme called the transpeptidaseenzyme which is involved in the synthesis of the bacterial cellenzyme which is involved in the synthesis of the bacterial cellwallwall
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TheThe
-lactam ring is involved in the mechanism of inhibition-lactam ring is involved in the mechanism of inhibition
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Penicillin becomes covalentl linked to the enz me’s active sitePenicillin becomes covalentl linked to the enz me’s active site
Covalent bond formedCovalent bond formedto transpeptidase enzymeto transpeptidase enzyme
NSMeMeHNH HCO
2
HOCORNuEnz
CHNCCO
2
HHHMeMeSHNORONu-Enz
-H
NSMeMeHNH HCO
2
HOCHEnz-NuOR
Mechanism oMechanism of
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