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THE SOURCE:
Malaria is an infectious disease caused by a one called parasite known as Plasmodium. The parasite is transmitted to humans by the bite of the female Anopheles mosquito. The parasite plasmodium spends its cycle life partly in humans and partly in mosquitoes. The Cycle: 1. Mosquito infected with the malaria parasite bites human, passing cells called sporozoites into the humans bloodstream. 2. Sporozoites travel to the liver. Each sporozoite undergoes sexual reproduction, in which its nucleus splits to form two new cells, called merozoites. 3. Merozoites enter to the bloodstream and infect red blood cells. 4. In red blood cells, merozoites grow and divide to produce more merozoites, eventually, causing the red blood cells to rupture. Some of the newly released merozoites go on to infect other red blood cells. 5. Some merozoites develop into sex cells known as male and female gametocytes. 6. Another mosquito bites the infected human, ingesting the gametocytes. 7. In the mosquitos stomach, the gametocytes mature. Male and female gametocytes undergo sexual reproduction, uniting to form a zygote. The zygote multiplies to form sporozoites, which travel to the mosquitos salivary glands. 8. If this mosquito bites another human, the cycle begins again.
SEQUENCE EXPLANATION
The Cycle: 1. Mosquito infected with the malaria parasite bites human, passing cells called sporozoites into the humans bloodstream. 2. Sporozoites travel to the liver. Each sporozoite undergoes sexual reproduction, in which its nucleus splits to form two new cells, called merozoites. 3. Merozoites enter to the bloodstream and infect red blood cells. 4. In red blood cells, merozoites grow and divide to produce more merozoites, eventually, causing the red blood cells to rupture. Some of the newly released merozoites go on to infect other red blood cells. 5. Some merozoites develop into sex cells known as male and female gametocytes. 6. Another mosquito bites the infected human, ingesting the gametocytes. 7. In the mosquitos stomach, the gametocytes mature. Male and female gametocytes undergo sexual reproduction, uniting to form a zygote. The zygote multiplies to form sporozoites, which travel to the mosquitos salivary glands. 8. If this mosquito bites another human, the cycle begins again.
HUMA N
HUMANS BLOODSTREAM
t r a v e l t o
bloodstream
MEROZOITES
MORE MEROZOITES
To form
Nucleus Splits
LIVER
ruptur e infect
Mature & undergo sexual reproduction to form
develop
Z Y G O TE
Mosquito Stomach
to the
Gametocyt es
HUMAN
i n f e c t e d
SPOROZOITES
Salary Glands