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PENICILLINSPENICILLINS
Beta- lactam antibioticsBeta- lactam antibioticsDerivatives of 6- aminopenicillanic acidDerivatives of 6- aminopenicillanic acid: Alteration of the side group resulted in cpds with: Alteration of the side group resulted in cpds with Broader spectrum of activityBroader spectrum of activity Resistance to penicillinaseResistance to penicillinase Stability in acid PHStability in acid PHMost widely effective antibioticsMost widely effective antibioticsLeast toxic drugs knownLeast toxic drugs known
 
 
 
 
MECHANISM OF ACTIONMECHANISM OF ACTION
They act by inhibition of bacterial cell wall synthesisThey act by inhibition of bacterial cell wall synthesisThus exposing the osmotically less stable membraneThus exposing the osmotically less stable membraneThis cause lysis of bacterial cell wallThis cause lysis of bacterial cell wallThese agents are bactericidalThese agents are bactericidalActive against multiplying and not resting bacteriaActive against multiplying and not resting bacteria Inactive against mycobacteria, protozoa, fungi andInactive against mycobacteria, protozoa, fungi andvirusesviruses
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