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Stem Cells

Stem Cells

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Published by Trip Adler

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Published by: Trip Adler on Nov 10, 2006
Copyright:Attribution Non-commercial

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02/05/2013

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The Multi-step Model of Leukocyte -EndothelialInteractions
LeukocyteLeukocytein flow in flow 
(1a) Tethering(1a) Tethering
BloodBlood
(1b) Rolling(1b) Rolling(3) Firm adhesion(3) Firm adhesion
LeukocyteLeukocytein tissuein tissue
(4) Transmigration(4) TransmigrationChemotaxisChemotaxis
FLOW FLOW 
(2) Activation(2) Activation
Inflamed TissueInflamed Tissue
 
 
Seeding
 
BM Matrix
Hematopoietic Cell Engraftment in Bone Marrow
Endothelial cells
 
 
Homing” of HSCsHoming” of HSCs
Bone marrow - identifiable by the fat cells,Bone marrow - identifiable by the fat cells,clusters of developing blood cells, and theclusters of developing blood cells, and thelarge megakaryocytes. Also, in the middlelarge megakaryocytes. Also, in the middleof the field is aof the field is a cross section of a sinusoidcross section of a sinusoidfilled with rbc's.filled with rbc's.Sinusoid of bone marrow seen here inSinusoid of bone marrow seen here inlongitudinal section. There is a nucleus of alongitudinal section. There is a nucleus of alining endothelial cell near the lower centerlining endothelial cell near the lower centerof the field. Junctions between endothelialof the field. Junctions between endothelialcells are loose so that HSCs can enter andcells are loose so that HSCs can enter andexit the blood vessels.exit the blood vessels.

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