INFLAMMATORY MEDIATOR

Epidermal growth factor (EGF)

Main origins Activated macrophages Salivary glands Keratinocytes Effects Keratinocyte and fibroblast mitogen Keratinocyte migration Granulation tissue formation

Transforming growth factor- (TGF-)

Main origins Activated macrophages T-lymphocytes Keratinocytes Effects Hepatocyte and epithelial cell proliferation Expression of antimicrobial peptides Expression of chemotactic cytokines

Hepatocyte growth factor (HGF)

Main origins Mesenchymal cells Effects Epithelial and endothelial cell proliferation Hepatocyte motility

Vascular endothelial growth factor (VEGF)

Main origins Mesenchymal cells Effects Vascular permeability Endothelial cell proliferation

Platelet derived growth factor (PDGF)

Main origins Platelets Macrophages Endothelial cells Smooth muscle cells Keratinocytes Effects Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis Granulocyte, macrophage and fibroblast activation Fibroblast, endothelial cell and smooth muscle cell proliferation Matrix metalloproteinase, fibronectin and hyaluronan production Angiogenesis Wound remodeling Integrin expression regulation

Fibroblast growth factor 1 and 2 (FGF 1&2)

Main origins Macrophages Mast cells T-lymphocytes Endothelial cells Fibroblasts Effects Fibroblast chemotaxis Fibroblast and keratinocyte proliferation Keratinocyte migration Angiogenesis Wound contraction Matrix deposition

Transforming growth factor- (TGF-)

Main origins Platelets T-lymphocytes Macrophages Endothelial cells Keratinocytes Smooth muscle cells Fibroblasts Effects Granulocyte, macrophage, lymphocyte, fibroblast and smooth muscle cell chemotaxis TIMP synthesis Angiogenesis Fibroplasia Matrix metalloproteinase production inhibition Keratinocyte proliferation

Keratinocyte growth factor (KGF)

Main origins Keratinocytes Effects Keratinocyte migration, proliferation and differentiation