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CHEMICAL MRID STUDY TYPEGUIDELINENO.COMPART-MENTSEX TIMETIME-UNITDOSEACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 21 D 0ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 21 D 0.33ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 21 D 3.31ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 21 D 48.63ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 28 D 0ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 28 D 0.12ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 28 D 0.28ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 28 D 0.58ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 28 D 8.9ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 42 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 42 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 42 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 42 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 49 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 49 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 49 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 49 D 35ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 49 D 0ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 49 D 0.33ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 49 D 3.31ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 49 D 48.63ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 63 D 0ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 63 D 0.12ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 63 D 0.28ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 63 D 0.58ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 63 D 8.9ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 91 D 0ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 91 D 0.12ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 91 D 0.28ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 91 D 0.58ACEPHATE 40504819 SUBCHRONICORAL 82-1 RBC M 91 D 8.9ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 91 D 0ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 91 D 0.33ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 91 D 3.31ACEPHATE 44203304 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 91 D 48.63ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 133 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 133 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 133 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 133 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 196 D 0

U.S. EPA Office of Pesticide Programs

CHEA=cholinesterase activityCHUNIT=cholinesterase activity units

Spreadsheet Containing the Male RBC Data Used in the Preliminary Cumulative HazardResponse Assessment for Organophosphorus Pesticides. July 31, 2001

TIME= day at which measurement was takenTIMEUNIT=day (D)7/31/01 1

CHEMICAL MRID STUDY TYPEGUIDELINENO.COMPART-MENTSEX TIMETIME-UNITDOSEACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 196 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 196 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 196 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 364 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 364 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 364 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 364 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 546 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 546 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 546 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 546 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 637 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 637 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 637 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 637 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 728 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 728 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 728 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 728 D 35ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 819 D 0ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 819 D 0.25ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 819 D 2.5ACEPHATE 84017 COMBINEDCHRONICORAL 83-5 RBC M 819 D 35AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 24 D 0AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 24 D 0.91AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 24 D 2.81AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 24 D 7.87AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 30 D 0AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 30 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 30 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 30 D 2.33AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 87 D 0AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 87 D 0.91AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 87 D 2.81AZINPHOSMETHYL 43826601 SUBCHRONICNEUROTOXICITYORAL 82-7 RBC M 87 D 7.87AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 90 D 0AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 90 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 90 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 90 D 2.33AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 180 D 2.33AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 360 D 2.33AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 540 D 0AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 540 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 540 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 540 D 2.33AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 720 D 0

7/31/01 2

CHEMICAL MRID STUDY TYPEGUIDELINENO.COMPART-MENTSEX TIMETIME-UNITDOSEAZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 720 D 0.25AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 720 D 0.75AZINPHOSMETHYL 41119901 COMBINEDCHRONICORAL 83-5 RBC M 720 D 2.33BENSULIDE 43919601 SUBCHRONICORAL 82-1 RBC M 91 D 0BENSULIDE 43919601 SUBCHRONICORAL 82-1 RBC M 91 D 5BENSULIDE 43919601 SUBCHRONICORAL 82-1 RBC M 91 D 15BENSULIDE 43919601 SUBCHRONICORAL 82-1 RBC M 91 D 46BENSULIDE 43919601 SUBCHRONICORAL 82-1 RBC M 91 D 110BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 175 D 0BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 175 D 1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 175 D 15.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 175 D 60.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 357 D 0BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 357 D 1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 357 D 15.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 357 D 60.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 539 D 0BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 539 D 1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 539 D 15.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 539 D 60.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 721 D 0BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 721 D 1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 721 D 15.1BENSULIDE 44161101 COMBINEDCHRONICORAL 83-5 RBC M 721 D 60.1CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 350 D 0CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 546 D 0CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 728 D 0CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 43 D 0CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 43 D 0.1CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 43 D 1CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 43 D 5CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 43 D 15CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 90 D 0CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 90 D 0.1CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 90 D 1CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 90 D 5CHLORPYRIFOS 40952801 SUBCHRONICORAL 82-1 RBC M 90 D 15CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0.05CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 180 D 0.1CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 180 D 1CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 180 D 10CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 350 D 0CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 350 D 0.0132CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 350 D 0.33CHLORPYRIFOS 42172802 COMBINEDCHRONICORAL 83-5 RBC M 350 D 6.773CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0.05CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 360 D 0.1CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 360 D 1CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 360 D 10CHLORPYRIFOS 40952802 COMBINEDCHRONICORAL 83-5 RBC M 540 D 0

7/31/01 3

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Environmental Protection Agency: OPcholinesteraseRBCmalexl

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