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Home/PLoS ONE,Science/Tech/Health/ Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa <italic>In Vitro</italic>
Mobile Phone Radiation Induces Reactive OxygenSpecies Production and DNA Damage in HumanSpermatozoa <italic>In Vitro</italic>
ByPLoS ONE• on July 31, 2009BackgroundIn recent times there has been some controversy over the impact of electromagnetic radiation on humanhealth. The significance of mobile phone radiation on male reproduction is a key element of this debate sinceseveral studies have suggested a relationship between mobile phone use and semen quality. The potentialmechanisms involved have not been established, however, human spermatozoa are known to be particularlyvulnerable to oxidative stress by virtue of the abundant availability of substrates for free radical attack andthe lack of cytoplasmic space to accommodate antioxidant enzymes. Moreover, the induction of oxidativestress in these cells not only perturbs their capacity for fertilization but also contributes to sperm DNAdamage. The latter has, in turn, been linked with poor fertility, an increased incidence of miscarriage andmorbidity in the offspring, including childhood cancer. In light of these associations, we have analyzed theinfluence of RF-EMR on the cell biology of human spermatozoa in vitro.Principal FindingsPurified human spermatozoa were exposed to radio-frequency electromagnetic radiation (RF-EMR) tuned to1.8 GHz and covering a range of specific absorption rates (SAR) from 0.4 W/kg to 27.5 W/kg. In step withincreasing SAR, motility and vitality were significantly reduced after RF-EMR exposure, while themitochondrial generation of reactive oxygen species and DNA fragmentation were significantly elevated(
 P 
<0.001). Furthermore, we also observed highly significant relationships between SAR, the oxidative DNAdamage bio-marker, 8-OH-dG, and DNA fragmentation after RF-EMR exposure.ConclusionsRF-EMR in both the power density and frequency range of mobile phones enhances mitochondrial reactiveoxygen species generation by human spermatozoa, decreasing the motility and vitality of these cells whilestimulating DNA base adduct formation and, ultimately DNA fragmentation. These findings have clear implications for the safety of extensive mobile phone use by males of reproductive age, potentially affecting both their fertility and the health and wellbeing of their offspring.For the full article visit:Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNADamage in Human Spermatozoa <italic>In Vitro</italic>Syndicated from:PLoS ONEArticle is licensed under aCreative Commons Attribution License.
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