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Cardiovascular Bio Markers Handbook

Cardiovascular Bio Markers Handbook

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Published by: prakashbioc on Aug 10, 2009
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02/06/2013

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SAS Centres forCardiovascularBiomarkersHandbook
 
SAS Cardiovascular Biomarkers Handbook 
1
Index
Preface2Contact details3Laboratory profiles5Specimen requirements and assay availability9Abrief introduction to lipoprotein metabolism10Characteristics of major lipoproteins11Physiological functions of the major lipoproteins11Characteristics of major apolipoproteins12Function of major enzymes of lipoprotein metabolism 12Lipoprotein metabolism- Exogenous pathway13- Endogenous pathway14Primary causes of dyslipidaemia15Secondary causes of dyslipidaemia16Investigation protocol for dyslipidaemia17Brief details of available assays:Apolipoprotein A118Apolipoprotein B20Apolipoprotein E polymorphisms22Beta - Quantification (Ultracentrifugation)23Homocysteine 25LDL(Calculated and Direct)27Lipoprotein (a)28Lipoprotein Lipase 30Appendix - non-core assays
 
2
Preface
This handbook has been produced as a guide for clinicians and laboratory staff involvedin the investigation of dyslipidaemias and in the assessment of cardiovascular risk. Thenetwork of SAS centres for cardiovascular biomarkers was set up in response to anincreasing demand for tests other than the routine lipid profile to aid in the assessmentand management of patients.The aim of this handbook is not only to list available tests and the laboratories whichoffer them, but also to give a brief description of the tests, the circumstances in whichthey are indicated and interpretation of the results.More information is available in specialist textbooks of clinical chemistry and lipoproteinmetabolism1.Betteridge DJ, Illingworth DR, Shepherd J. Lipoproteins in Health and Disease.Arnold 19992.Rifai N, Warnick GR, Dominiczak M. Handbook of Lipoprotein 2nd edition ; AACCPress 20003.Ordovas JM. Lipoprotein Protocols ; Methods in Molecular Biology Vol 110.HumanaPress 1998Updated information on this new SAS service is available on the SAS website:
www.sas-centre.org
SAS Cardiovascular Biomarkers Handbook 

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