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Teratogenic potency of drugs and other disadvantages

Drug dosage and the ability to cross the placenta


The stadium of pregnancy

General condition of the mother.

Elimination :
Renal blood flow and GFR increase Steady state only slight declines but the dosage does not need increase

Drug could damage the fetus : 1. Directly

2. Indirectly

Placental determinants

Drug determinants

Area exchange

Molecular weight < 600

Thickness of membranes

Lipid soluble

Enzyme systems

Non-charged, basic

Death => abortion Malformation / anomalies

Retardation

Changing in behavior

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