Use of some antimicrobial preservatives Benzoic Acid:
Benzoic acid (C7H6O2) is used as a pharmaceutical preservative for its antifungal properties. Benzoic acid and its salts inhibit the growth of bacteria, yeast and mold. It is used in chemically based ointments to treat fungal diseases, such as athlete's foot, ringworm and tinea. A 0.1 percent concentration of benzoic acid is used in pharmaceutical applications. It is used as an antiseptic in mouthwashes and lotions.
Ethyl paraben or ethyl para-hydroxybenzoate, is an antimicrobial preservative most commonly used in cosmetics and pharmaceutical formulations. It is an antifungal agent and found as a white crystalline powder. Ethyl paraben is used as a stand-alone agent or in combination with other antimicrobials and parabens. It is ineffective against molds and yeasts.
Methylparaben, also methyl paraben is a preservative. It is an anti-fungal agent often used in a variety of cosmetics and personal-care products. It is readily absorbed from the gastrointestinal tract or through the skin. It does not accumulate in the body. Acute toxicity studies have shown that methylparaben is practically non-toxic by both oral and parenteral administration in animals. Studies indicate that methylparaben applied on the skin may react with UVB, leading to increased skin aging and DNA damage.
Butyl paraben combats mold, fungus and bacteria in pharmaceuticals, cosmetics, food and other products. It has been shown to be non-toxic when used as .05 percent of a solution, but if a stronger solution is used it can irritate the skin. Exposure to butyl paraben also adversely affects the male reproductive system as well as the production of testosterone, the principal male sex hormone.
Antioxidants are included in the pharmaceutical products to prevent deterioration from oxidation. Antioxidants are classified into 3 groups. The first group is known as true antioxidants, or anti-oxygen, probably inhibit oxidation by reacting with free radicals blocking the chain reaction. Examples are alkygallates butylated hydroxyanisol, butylated hydroxytoluene, nordihydroguaiaretic acid and the tocopherols. The second group consists of reducing agents; these substances have lower redox potentials than the drug or adjuvant which they are intended to protect, and are therefore, more readily oxidized. Reducing agents may act also by reacting with free radicals. Examples are ascorbic acid, the potassium and sodium salts of sulphurous acid. The third group consists of antioxidant synergists which usually have little antioxidant effect themselves but probably enhance the action of antioxidants in the first group by reacting