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Diclofenac

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Diclofenacul prezint un "efect al primului pasaj" substanial, astfel c doar 50% din cantitatea administrat ajunge n circulaia sistemic.

E creia renal este responsabil pentru cea mai mare parte din cantitile eliminate, rata eliminrii fiind diminuat la pacienii !"rstnici #i cei cu insuficien renal. $pro imati! %5% din cantitatea de metabolii ai diclofenacului este eliminat la ni!el biliar.

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