infection from the vertebral body but in children it can be a primary site, as the disc isvascular in children.It is the commonest place for tuberculosis to affect the skeletal system although it canaffect the hips and knees too. The usual sites to be involved are the lower thoracic andupper lumbar vertebrae.The infection spreads from two adjacent vertebrae into the adjoining disc space. If onlyone vertebra is affected, the disc is normal, but if two are involved the disc between themcollapses as it is avascular and cannot receive nutrients. Caseation occurs, with vertebralnarrowing and eventuallyvertebral collapseand spinal damage. A dry soft tissue massoften forms and superinfection is rare.
Epidemiology
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Pott's disease is rare in the UK but in developing countries it represents about 2%of cases of tuberculosis and 40 to 50% of musculoskeletal tuberculosis.
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Tuberculosis worldwide accounts for 1.7 billion infections, and 2 million deaths per year.
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Over 90% of TB occurs in poorer countries, but a global resurgence is affectingricher ones.
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India, China, Indonesia, Pakistan and Bangladesh have the largest number of cases but there has been a marked increase in the number of cases in the former Soviet Union and in sub-Saharan Africa in parallel with the spread of HIV.
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The disease affects males more than females in a ratio of between 1.5 and 2:1. Inthe USA it affects mostly adults but in the countries where it is commonest itaffects mostly children.
Risk factors
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Poor socio-economic conditions
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Presentation
Symptoms
The onset is gradual.
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Fever
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Night sweats
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Anorexia
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Weight loss
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