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Hematology and Oncology

Hematology and Oncology

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Published by MedSchoolStuff
First Aid for the USMLE Step 1
2011 EXPRESS Workbook
First Aid for the USMLE Step 1
2011 EXPRESS Workbook

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Published by: MedSchoolStuff on Dec 10, 2013
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06/14/2014

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First Aid for the
® 
 USMLE Step 1 2011 EXPRESS workbook
page 125
Copyright © 2011 by MedIQ Learning, LLC All rights reserved
Hematology and Oncology
ANATOMY
1. In the chart below, checkmark which types of blood cells are derived from myeloid vs. lymphoid stem cells.
(p. 342)
 
Blood Cell Type Myeloid Lineage Lymphoid Lineage
B cell Basophil Erythrocyte Eosinophil Monocyte Natural killer cell Neutrophil Platelet T cell 2. List the types of white blood cells in order of decreasing prevalence.
(pp. 342-343)
 _____________  ______________________________________________________________________________ 3. Define the follow terms.
(pp. 342-343)
  A. Anisocytosis _______________________________________________________________ B. Eosinophilia _______________________________________________________________ C. Leukocytosis _______________________________________________________________ D. Poikilocytosis ______________________________________________________________ E. Thrombocytopenia __________________________________________________________ 4. What is the typical WBC count?
(p. 342)
 ______________________________________________ 5. What five conditions can cause eosinophilia?
(p. 343)
 ___________________________________  ______________________________________________________________________________ 6. B lymphocytes are produced in the _______________ (bone marrow/thymus) and mature in the  _______________ (bone marrow/thymus). T lymphocytes are produced in the _______________ (bone marrow/thymus) and mature in the _______________ (bone marrow/thymus).
(p. 344)
 
Questions
 
page 126
First Aid for the
® 
 USMLE Step 1 2011 EXPRESS workbook 
 
Copyright © 2011 by MedIQ Learning, LLC All rights reserved
PHYSIOLOGY
7. Why are Rh-negative mothers given RhoGAM
®
?
(p. 345)
 _________________________________ 8. In the chart below, checkmark which coagulation factors are in the intrinsic vs. extrinsic coagulation pathways.
(p. 345)
 
Factor Extrinsic Pathway Intrinsic Pathway Both Pathways
I II V VII VIII IX X XI XII 9. What factors are vitamin K dependent?
(p. 345)
 ________________________________________ 10. Describe the four steps of primary hemostasis and platelet plug formation.
(p. 346)
 ____________  ______________________________________________________________________________
PATHOLOGY
11. Identify each cell type and its associated pathology.
(pp. 348-349)
  A. B. C. D E. F.  A. _______________________________ D. ______________________________ B. _______________________________ E. ______________________________ C. _______________________________ F. ______________________________ 12. Indicate whether the lab findings in the chart are elevated, decreased, or normal.
(pp. 349-353)
 
Lab Value Anemia of Chronic Disease Hemochroma-tosis Iron Deficiency Pregnancy/ OCPs Thalassemia
Ferritin Serum iron Transferrin % Transferrin
 
First Aid for the
® 
 USMLE Step 1 2011 EXPRESS workbook
page 127
Copyright © 2011 by MedIQ Learning, LLC All rights reserved
13. In
α
-thalassemia, what is the condition called when all four
α
-globin genes are deleted? When three are deleted? When one or two are deleted?
(p. 349)
 ________________________________  ______________________________________________________________________________ 14. What are the major history and physical exam findings of lead poisoning?
(p. 350)
 _____________  ______________________________________________________________________________ 15. What clinical findings differentiate megaloblastic anemia due to folate deficiency versus that due to vitamin B
12
 deficiency?
(p. 350)
 _____________________________________________________ 16. What are four causes of aplastic anemia?
(p. 351)
 ______________________________________  ______________________________________________________________________________ 17. Match the intrinsic hemolytic normocytic anemia with its characteristic.
(p. 352)
  _____ A. G6PD deficiency 1. GLU
 LYS mutation  _____ B. HbC defect 2. GLU
 VAL mutation  _____ C. Hereditary spherocytosis 3. Heinz bodies  _____ D. Paroxysmal nocturnal hemoglobinuria 4. Howell-Jolly bodies  _____ E. Pyruvate kinase deficiency 5. Increased hemosiderin in urine  _____ F. Sickle cell anemia 6. Rigid RBCs 18. Which autoimmune hemolytic anemias are associated with warm agglutinins? With cold agglutinins?
(p. 353)
 ______________________________________________________________  ______________________________________________________________________________ 19. What are the
“5 P’s”
of acute intermittent porphyria?
(p. 354)
 ______________________________  ______________________________________________________________________________ 20. Indicate whether the lab findings in the chart are elevated, decreased, or normal.
(pp. 355-356)
 
Disorder Platelet Count Bleeding Time PT PPT
DIC
Glanzmann’s
thromboasthenia Hemophilia ITP/TTP Vitamin K deficiency
von Willebrand’s disease
 21. What type of cell is shown in the image? In what condition is this cell seen?
(p. 357)
  ___________________________________  ___________________________________  ___________________________________

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