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Survey on California's Shared Stem Cell Lab Program

Survey on California's Shared Stem Cell Lab Program

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Published by DavidJensen
Backers of the shared lab program funded by the California stem cell agency have opposed a proposal to end the program. Here is a survey prepared by the supporters concerning the use of the labs.
Backers of the shared lab program funded by the California stem cell agency have opposed a proposal to end the program. Here is a survey prepared by the supporters concerning the use of the labs.

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Published by: DavidJensen on Dec 10, 2013
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December 10, 2013 Compiled by K. Willert, UCSD 1 SUMMARY: Survey of CIRM-funded Shared Facilities 17 centers, 15 responses 1. What are the three most significant accomplishments of your Stem Cell Core that have added to the scientific infrastructure for Regenerative Medicine in California?
 Increasing hESC research activities, including for non-CIRM funded scientists.
 Training stem cell scientists and technical staff, who then contribute to the workforce.
 Supporting activities of CIRM Disease Teams and Bridges Training.
 Providing consultation and a “fast start” for stem cell projects, i.e. test the water/accelerate entry before committing whole-heartedly.
 Facilitating a highly collaborative and multidisciplinary environment where new ideas and projects originate.
 Developing, evaluating and standardizing new protocols and technologies for stem cell research.
 Sharing resources with other institutions (e.g. banked and GMP level hESCs iPSCs).
 Established centers with high-end technologies have helped in recruitment of stem cell scientists. 2. Do you want to seek continued funding for your Stem Cell Core from CIRM?
 All 15 responders replied with “yes”. 3. What do you see as the most significant value that a shared stem cell facility offers to regenerative medicine and stem cell science in California?
 Enabling and accelerating stem cell research.
 Generating preliminary data to attract funding.
 Training the next generation of stem cell scientists.
 Promoting collaboration.
 Hub/nucleus for information exchange among new and experienced researchers.
 Offering time and cost savings.
 Providing space and high-end instrumentation for stem cell research.
 Offering complete access to technology most grant writing labs cannot afford on their own.
 Highly trained technical staff that operate and maintain equipment.
 Offering standardized technologies in order to overcome hurdles and achieve reproducible successes.
 These facilities are absolutely essential for keeping California at the forefront of hIPSC research. 4. What is your priority if Shared Laboratories funding were to be extended. For example, for UCSD, we’d seek funds for personnel?
 Support for personnel: 15
 Service contracts on high-end equipment: 5
 Supplies and reagents: 1
 Overhead costs: 1 5. What Federal grants you have obtained as a result of CIRM funding your Stem Cell Core under the Shared Labs and Stem Cell Techniques Course RFA 07-01?
 Total = ~125
December 10, 2013 Compiled by K. Willert, UCSD 2 6. What is the method you have used to achieve financial sustainability so far?
 CIRM Shared Facilities Grant
 Traditional recharges for equipment use and services (e.g. teratoma formation, myco testing, iPS derivation)
 Rates based on individual lab’s use of basal media
 Cost recovery for supplies and materials only.
 Other grants, private and institutional funds.
 Philantropy 7. What is the number of publications resulting from work in your Stem Cell Core?
 Total = 440 8. What is the number of labs you count as major users of your Stem Cell Core?
 Total = 352 (14 labs reported numbers) 9. What is your Annual recharge revenue for your Stem Cell Core?
 Total = $1,630,000 (9 labs reported numbers) 10. How much is your Institutional matching support?
 No matching funds: 6 institutes
 Matching funds total at 6 institutes: $4.5+ M
December 10, 2013 Compiled by K. Willert, UCSD 3  ALL COMMENTS 1. What are the three most significant accomplishments of your Stem Cell Core that have added to the scientific infrastructure for Regenerative Medicine in California?  A: Having a significant impact on [the institute]'s stem cell and regenerative medicine program. Training stem cell scientists. Sharing resources with other institutions.  A: Stem cell therapy for Age-related Macular Degeneration (CIRM Disease Team). Neurodegenerative disease-specific iPSCs. Scaffolds/defined substrates for stem cell culture  A: It led to the creation of a new stem cell center, the [] Institute for the Biology of Stem Cells, which has seeded additional stem cell projects on the campus. This increase in the quality and quantity of stem cell research led to the need for additional stem-cell-focused research space on campus, provided in the form of a dedicated floor in our new biomedical sciences building and a new, improved vivarium. We acquired equipment and instrumentation that helped in successfully recruiting additional stem cell faculty. For our core facilities, we have hired experts in stem cell research and high-end instrumentation who have facilitated and enhanced stem cell research in several laboratories.  A: We have increased embryonic stem cell research on campus 250% since 2010, bringing in studies involving Retinoblastoma, Ewings Sarcoma, Spina bifida, Acute Lymphoblastic Leukemia, and a collaboration with [ ] working towards a phase I-II stem cell-mediated therapy for high-grade glioma clinical trials. We have provided training and research support for students in the Early Investigators High School program, CIRM Bridges program, doctoral students and researchers at [the institute], encouraging stem cell research at this institution as well as out side of this institution. We have begun building a pediatric disease specific iPSC bank that will be available to outside researchers. With the large range of pediatric diseases we see at [the institute], it is important we leverage our unique situation to push the research and treatments of childhood disease.  A: Brought together a critical mass of researchers learning and applying cutting edge stem cell techniques to answer outstanding questions about the biology of pluripotency, cell fate determination, and/or molecular and cellular underpinnings of their disease of interest. Received, disseminated and standardized emerging stem cell technologies and material/equipment resources from around the world for use by researchers with specific applications regardless of those researcher's ability to access and test these technologies in their own laboratories. Training of researchers in iPSC generation has had a major effect on the community. Created and maintained an environment where scientists from various disciplines (molecular/cell biology, biochemistry, chemistry, engineering, genetics) and with a variety of expertise are encouraged and supported to work together to accelerate technology and overcome hurdles in order to achieve their unique stem cell-related goals.  A: Our Stem Cell Core has trained 134 researchers in the “hands on” art of human pluripotent stem cell culture, reprogramming and directed differentiation. These researchers have come from 23 different research groups at our Institute, only 7 of which have received CIRM funding. It is important to emphasize the importance the stem cell core facility provides to enabling access to stem cell research to a very broad range of research groups that otherwise would not have had such opportunities. The Stem Cell Core has been the vehicle to introduce and evaluate new technologies and make them widely available to the research community. An initial focus of our Core was centered around the development of viral vector technologies and their specific application to stem cell research. Later we have focused on the evaluating and developing emerging technologies for achieving efficient reprogramming of human cell samples. Finally the development and sharing of techniques for directing differentiation to specific cell

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