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h1n1 Guidelines Pharmaceutical Mngt

h1n1 Guidelines Pharmaceutical Mngt

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Published by glastolully
the World Health Organisation meeting recently, all the report that they decided could be released to officials and the media.
the World Health Organisation meeting recently, all the report that they decided could be released to officials and the media.

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Published by: glastolully on Aug 31, 2009
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02/07/2013

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WHO Guidelines forPharmacological ManagementoPandemic (H1N1) 2009Influenza and other InfluenzaViruses
20 August 2009
 
 
 
 
Table
 
of
 
contents
 
....................................................................................................................................i
 
EXECUTIVE SUMMARY
...................................................................................................................................................iii
 
Other
 
recommendations
.............................................................................................................................................1
 
1. INTRODUCTION.....................................................................................................................................3
 
2. CASE DESCRIPTION
.................................................................................................................................................. 3
 
Uncomplicated
 
influenza...................................................................................................................................... 3
 
Complicated
 
or
 
severe
 
influenza................................................................................................................... 3
 
Signs
 
and
 
symptoms
 
of
 
progressive
 
disease
3. TREATMENT OF SEASONAL OR PANDEMIC INFLUENZA: RECOMMENDATIONS FOR USEOF ANTIVIRALS.................................................................................................................................................5
 
3.1
 
................................................................................................................................ 6
 
Use
 
of
 
oseltamivir
treatment3.2
 
Use
 
of
 
zanamivir
treatment.................................................................................................................................. 8
 
3.3
 
............................................................................................................................... 9
 
Use
 
of
 
amantadine
treatment3.4
 
.............................................................................................................................. 9
 
Use
 
of
 
rimantadine
treatment3.5
 
....................... 10
 
Treatment
 
recommendations:
 
Influenza
 
pandemic
 
(H1N1)
 
2009
 
influenza
 
virus
 
infection3.6
 
........................................................................... 12
 
Treatment
 
recommendations:
 
Other
 
influenza
 
virus
 
strains
16
 
4. CHEMOPROPHYLAXIS OF INFLUENZA: RECOMMENDATIONS FOR USE OF ANTIVIRALS
4.1
 
.............................................................................................................. 17
 
Use
 
of
 
oseltamivir
chemoprophylaxis4.2
 
................................................................................................................ 18
 
Use
 
of
 
zanamivir
chemoprophylaxis4.3
 
............................................................................................................. 18
 
Use
 
of
 
amantadine
chemoprophylaxis4.4
 
............................................................................................................ 19
 
Use
 
of
 
rimantadine
chemoprophylaxis4.5
 
................................................................................................................ 19
 
Chemoprophylaxis
 
recommendations..................................................................................................................................... 22
 
4.6
 
Summary
 
table
 
for
 
antiviral
5. OTHER INTERVENTIONS FOR MANAGEMENT OF PATIENTS WITH INFLUENZA.................24
 
......................................................................................................................................26
 
6. PRODUCT SUPPLY........................................................................................................................28
 
7. PRIORITIES FOR UPDATE
................................................................................................................................... 28
 
Plans
 
for
 
updating
 
this
 
guideline.......................................................................................................... 28
 
Updating
 
or
 
adapting
 
recommendations
 
locally
...................................................................................................................30
 
8. PRIORITIES FOR RESEARCH......................................................................34
 
ANNEX 1: METHODS USED TO PREPARE GUIDELINES
........................................................................................................... 36
 
Preparation
 
of
 
the
 
 background
 
documentation............................................................................................................................ 36
 
Identification
 
of
 
important
 
outcomes.................................................................................................................................................................. 37
 
Search
 
strategy......................................................................................................... 37
 
Selection
 
criteria,
 
data
 
collection
 
and
 
 judgments
............................................................................................................40
 
ANNEX 2: LIST OF PARTICIPANTS............................................................................................42
 
ANNEX 3: DECLARATIONS OF INTERESTS............................44
 
ANNEX 4: EVIDENCE SUMMARIES AND SUMMARIES OF FINDINGS TABLES..............................................................................76
 
ANNEX 5: SUMMARY OF OBSERVATIONAL DATA................................................................................80
 
ANNEX 6: TABLE OF RECOMMENDED DOSAGES....................................................................................................................................................82
 
REFERENCES
 

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