Professional Documents
Culture Documents
BORN
A 30 year old female had an abortion
at 25 weeks.Foetus on exam was
severly anaemic,had pleural effusions
and ascites(hydrop foetalis).The first
baby is alive and well but on
questioning the mother indicated that
the child was very “yellow” at birth
.Her blood group is O negative
.Husband’s is A positive. For some
unknown reason anti-D injection was
not given during the first pregnancy
or immediately after delivery.
QUESTIONS
RhoGAM vaccination
pathology
Initial exposure to foreign
antigen
Feto-maternal haemorrhage due
too
trauma,abortion,childbirth,medic
al procedures
B lymphocyte clones that
recognize red blood antigen are
established
Initially maternal antibody
production is of IgM
This is termed as the primary
response
Oncotic pressure
Portal hypertension
PLEURAL EFFUSION
Reduced oncotic pressure
CARDIAC
DYSRHYTHMIAS:Supraventricular
tachycardia, trial flutter, congenital
heart block
STRUCTURAL HEART
LESIONS:Premature closure of
foramen ovale, tricuspid
insufficiency
VASCULAR:thrombosis of umbilical
vein or inferior venacava, true knot
of umbilical cord
LYMPHATIC:Lymphangiectasia,
cystic hygromachylothorax, chylous
ascites
TERATOMAS:saccroccygeal
teratoma, Choriocarcinoma
CHROMOSOMAL
ABNORMALITIES:Trisomy 13,
15,16,18,21.
BONE DISEASES:Osteogenesis
imperfect, asphyxiating thoracic
dystrophy, skeletal dysplasia
CONGENITAL
INFECTIONS:Cytomegalo virus,
parvovirus B19, rubella,
OTHER CAUSES OF
HAEMOLYTIC DISEASE OF
THE NEWBORN
Haemolytic disease of the newborn
due to ABO incompatibility
Kell group antibodies(anti-K and
anti-k)Cause severe fetal
anaemia