& Schering-Plough ‘Schering-Plough ‘SAPHRIS® Speaker Bureau 2000 Galloping Hil Road Kenilworth, New J Telephone (908) ‘September 8, 2009 Daniel J. Carat, MD ‘Tufts University Schoo! of Medicine 42 Ploasant Streat Suite 8 Newburyport MA 01950 Dear Dr. Carfat We are proud to announce that SAPHRIS? (asenapine) sublingual tablets was approved by the U.S. Food and Drug Administration (FDA) for acute treatment of schizophrenia in adulls and acute treatment of manic or mixed episades associated with bipolar | disorder with or without psychotic features in adults on August 13, 2009. Please see the enclosed SAPHRIS Press Release and package insert for additional information. ‘As a recognized thought leader and well-respected healthcare professional among your peers, we are seeking your participation as {2 speaker in our Schering-Plough SAPHRIS Speaker's Bureau pursuant to the terms and conditions of the enclosed contract. We ‘would lke you to be a speaker in the Speakers Program because we believe itis important to have experts educate physicians and other healthcare professionals. We hope you will accept this invitation and join our group of respected speakers. The following points provide further information ‘about the Speakers Program: + Lectures may be local or roquite travel. Schering-Plough will reimburse you for reasonable travel, lodging and outo- ‘pocket expenses incurred while on company businoss. Speaker Programs must comply wih FDA regulations on promotional guidelines. ‘Alllectures in the speakere programe must use Schering approved material and remain within product labeling. ‘You wil be paid a speaker foo for your lecture as outlined in the attached contact. ‘We will make a sincare effort to request your sorvices atleast 30 days in advance of any lecture. Enclosed please find a Speaker Agreement and the Speaker Training Meeting Facuity Profile Form. ‘To expedite the contracting process, we ask that you complete the contract, the W® form, ‘and the Speaker Training Meeting Faculty Profile Form and fax back within 30 days to (908) 259-2326, Ploase keep the original document for your files. you wish to mail a copy instead of fax, please use the enclosed envelope or mail to Alin: USCOS Speaker Processing ~ K-5-1, C325 ‘Schering-Plough Corporation 2000 Galloping Hil Road Kenilworth, NJ 07033-9800 {you havo any questions, please contact the following: ‘© Travel Logistics: Shelley Huez 773-756-3000; shuez@ riverwestmestings.com ‘= Contract: Donna Rinaldo 908-298-2512; donna.rinaldo@socorp.com ‘© Allother questions: Ciga Mitelman 908-298-2646; olga mitelman@ spcorp.com ‘We are appreciative of your commitment to your patients and to Schering-Plough. Regards, eceracorenno GB spe seetcarea Seaveeaee Enclosures