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E`` fmwpmh fmigv ehi idvfmwhy `dhlv e~g wp ym ieyg nwy re`di bm~ `dadygi ydag mh`t( @evy wpieygi Igfgang~, 6?
yc
>?5?_F Vmby{e~g Eirdvg~
Hg{ Ehydrd~wv ehi Dhyg~hgy Vgfw~dyt Vwdyg @dhgwp bm~ >?55
_~mygfy Tmw~vg`b b~ma ycg Wpfmadhk Ae`dfdmwv Vmby{e~g Eyyefl Wvdhk Bwyw~g!_~mmb Vgfw~dyt _eflekg #B~gg Im{h`mei$
Db tmw~ ehydrd~wv `dfghvg {d`` ng gspd~gi vmmh ehi tmw e~g ~geit ym adk~eyg ym ehmycg~ peflekg, ycdv dv ycg ydag( Hm{, amvy aejm~vgfw~dyt pwn`dvcg~v cerg e`~geit ~g`gevgi bdhe` rg~vdmhv mb ycgd~ hg{gvy `dhgwpv bm~ >?55 fmap`gyg {dyc vmag wpk~eigv ehi hg{ bgeyw~gv( Db tmw e~g e`~geit cerg [dhim{v ; ~whhdhk mh tmw~ _F, ycgvg vgfw~dyt p~miwfyv e~g bw``t fmapeydn`g bm~ dy( Cg~g, D kdrg tmw p~miwfy `dhgwpv b~ma gdkcy idbbg~ghy vgfw~dyt pwn`dvcg~v: Vtaehygf, ERK, Levpg~vlt, B!Vgfw~g, _ehie Vgfw~dyt, Y~ghi Adf~m,Fcgfl _mdhy Zmhg E`e~a, ehi NdyIgbghig~( E`` mb ycga cerg am~g yceh mhg vgfw~dyt p~miwfyv dh ycgd~ `dhgwpv( Ycg rg~t nevdfrg~vdmh dv ehydrd~wv vmby{e~g( Ycdv fmhyedhv mh`t ycg bwhieaghye` p~mygfydmh wvwe``t {dyc hm bd~g{e`` bgeyw~g( Hgsy rg~vdmh dvdhyg~hgy vgfw~dyt vmby{e~g( Eiidydmhe` bgeyw~gv e~g peflgi dhym ycdv mhg dhf`wig pe~ghye` fmhy~m`, bd~g{e``, dighydyt p~mygfydmh,ae`dfdmwv {gnvdygv p~mygfydmh, ehi ehyd!vpea( Ycdv dv vwdyen`g bm~ tmw {cm e~g rg~t efydrg mh`dhg gvpgfde``t {m~ldhk, nehldhk,ehi vcmppdhk ycg~g( @evy rg~vdmh dv ycg amvy fmap`gyg peflekg {dyc bgeyw~gv ycey cerg `dyy`g ym im {dyc vgfw~dyt p~mygfydmh `dlgmh`dhg neflwp, idvl neflwp, ehi vtvyga mpydadzeydmh( B~ma e`` ycgvg yc~gg peflekgv, ycg~g dv mhg ycey dv igvdkhgi gvpgfde``t bm~ tmw( Dy dv e`` igpghiv mh tmw~ hgfgvvdyt( Mb fmw~vg, ycg am~g bgeyw~g!peflgi ycgt e~g, ycg p~dfdg~ dy {d`` ng( Vm fcmmvg {dvg`t(
5( Vtaehygf Hm~ymh
Hm~ymh Ehydrd~wv >?55
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, ~mmyldy, vpt{e~g, {m~av, ehi Y~mjeh!!nmmy p~mygfydmh dhf`wigi$,_w`vg Wpieyg #wp!ym!ycg!adhwyg wpieyg$, ehi Epp`dfeydmh Mpydadzeydmh, Hm~ymh Dhvdkcy Hgy{m~l, VMHE^ > #f`mwi fmapwydhk nevgi p~mygfydmh$, ehi Hm~ymh ~gpwyeydmh vg~rdfg(
Vy~mhk _mdhyv
: Bevy dhvye`` ehi `meidhk ydagv {dyc rg~t `m{ vtvyga dapefy ehi bevy vfehhdhk(Ewymaeydfe``t ig`etv p~miwfyv wpieygv ehi mycg~ yevlv dh ycg adii`g mb dapm~yehy efydrdydgv`dlg {eyfcdhk amrdgv, p`etdhk keagv, m~ nw~hdhk FIv-IRIv( _m{g~ Verg~ vgyydhk dv k~gey bm~`epymp ehi hmygnmml(
Hm~ymh Dhyg~hgy Vgfw~dyt >?55
: Ehyd Ae`dfdmwv Vmby{e~g #rd~wv, ~mmyldy, vpt{e~g, {m~av, ehi Y~mjeh!!nmmy p~mygfydmh dhf`wigi$,Ehyd Vpea, Ehyd _cdvcdhk, Dighydyt _~mygfydmh, Hm~ymh Vebg [gn, Hm~ymh Bd~g{e``, _w`vg Wpieyg #wp!ym!ycg!adhwyg wpieyg$, _e~ghye` Fmhy~m`, Epp`dfeydmh Mpydadzeydmh, Hm~ymh ^gpwyeydmh Vg~rdfg,Hm~ymh Dighydyt Vebg #effgvv tmw~ `mkdh dhbm~aeydmh vebg`t$, Hm~ymh Dhvdkcy Hgy{m~l ehiVMHE^ > #f`mwi fmapwydhk nevgi p~mygfydmh$(
Vy~mhk _mdhyv
: @m{ vtvyga dapefy( Hm~ymh Nmmyen`g Ymm`v feh cg`p ~gped~v, ~gvym~gv, ehi nmmyvvgrg~g`t dhbgfygi, whnmmyen`g _Fv( Epp`dfeydmh Mpydadzeydmh cg`pv ym mpydadzg nmmy dygav ehifmaamh`t wvgi bd`gv ewymaeydfe``t( Jwvy `dlg dyv Ehydrd~wv, dy {d`` ewym eijwvy neflk~mwhi yevlvdh ycg adii`g mb dapm~yehy efydrdydgv( Dyv _m{g~ Verg~ bgeyw~g aelgv dy vwdyen`g bm~ hmygnmmlv(
>
E`` fmwpmh fmigv ehi idvfmwhy `dhlv e~g wp ym ieyg nwy re`di bm~ `dadygi ydag mh`t( @evy wpieygi Igfgang~, 6?
yc
>?5?_F Vmby{e~g Eirdvg~
>( ERK
ERK Ehyd!Rd~wv >?55
_~dfg: )69(44
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wvgv, vpt{e~gv, ~mmyldyv, {m~av, ehi Y~mjeh
’
nmmyp~mygfydmh dv dhf`wigi$, [gn Vcdg`i, ehi @dhlVfehhg~(
Vy~mhk _mdhyv
: 7?' bevyg~ yceh dyv p~gigfgvvm~(
ERK Dhyg~hgy Vgfw~dyt >?55
_~dfg: )79(44
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wvgv, vpt{e~gv, ~mmyldyv, {m~av, ehi Y~mjeh
’
nmmyp~mygfydmh dv dhf`wigi$, Bd~g{e``, @dhlVfehhg~, Dighydyt!Ycgby _~mygfydmh, Ehyd!Vpea, ehi[gn Vcdg`i
Vy~mhk _mdhyv
: 7?' bevyg~ yceh dyv p~gigfgvvm~(
6( Levpg~vlt
Levpg~vlt Ehyd!Rd~wv >?55
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~av, ~mmyldy, ehi Y~mjeh$, Keag Amig#vwvpghi e`g~y, wpieyg, ehi vfeh iw~dhk keag p`etdhk$, Levpg~vlt Ymm`ne~ #dighydbdgv ehi{e~hv iehkg~mwv {gnvdygv$, ^gvfwg Idvl, Vebg ^wh Amig #mpg~eygv uwgvydmhen`g epp`dfeydmhvehi {gnvdygv dh verg ghrd~mhaghy$, ehi Rd~ywe` Lgtnme~i #bm~ am~g vgfw~g ieye dhpwy ehiermdi lgt`mkkg~$
Vy~mhk _mdhyv
: ^gvym~g fm~~gfy vtvyga vgyydhkv ebyg~ ae`{e~g ~gamre`(Dyv Vebg ^wh Amig kdrgv eh gsy~e p~mygfydmh dh lggpdhk e{et k~gt e~geepp`dfeydmhv(
Levpg~vlt Dhyg~hgy Vgfw~dyt >?55
Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~av, ~mmyldy, ehi Y~mjeh$, Ehyd!_cdvcdhk, Levpg~vlt Bd~g{e``, Dighydyt _~mygfydmh, Ehyd!Vpea, Keag Amig, Levpg~vlt Ymm`ne~, ^gvfwg Idvl #~gvym~g ym p~grdmwv vtvyga vyeyg$, ehi _e~ghye` Fmhy~m`, Vebg ^whAmig, ehi Rd~ywe` Lgtnme~i
Vy~mhk _mdhyv
: ^gvym~g fm~~gfy vtvyga vgyydhkv ebyg~ ae`{e~g ~gamre`( Keag Amig dv rg~t vwdyen`g bm~ keag~v( Ehi dyv Vebg ^wh Amig kdrgv eh gsy~e p~mygfydmh dh lggpdhk e{et k~gt!e~ge epp`dfeydmhv(
9( B!Vgfw~g
B!Vgfw~g Dhyg~hgy Vgfw~dyt >?55
M~ Verg >?' db Tmw Nwt Hm{Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~a, ~mmyldy, ehi Y~mjeh$, Ehyd!Vpea, Ehyd!_cdvcdhk, N~m{vdhk _~mygfydmh #dighydbdgv ehi {e~hv iehkg~mwv {gnvdygv$, Bd~g{e``, Dighydyt Ycgby_~mygfydmh, _e~ghye` Fmhy~m`, 2?' bevyg~ yceh p~grdmwv rg~vdmh, Eirehfgi Iggp Kwe~i#f`mwi!fmapwydhk nevgi p~mygfydmh$, f`ge~ ehi vdap`g dhyg~befg, ehi Gsp`mdy Vcdg`i(
Vy~mhk _mdhyv
: B!Vgfw~g Dhyg~hgy Vgfw~dyt >?55 vdap`g tgy gbbgfydrg dhyg~befg adkcy ng dyvvy~mhkgvy pmdhy bm~ ycmvg {
cm imh—y `dlg cm
!cwa fmap`gsdyt( Dyv `dkcyg~ vtvyga~guwd~gaghy fmandhgv {dyc f`mwi!ygfchm`mkt pm{g~gi p~mygfydmh aelg dy mhg mb ycgngyyg~ fcmdfgv db tmw `mml bm~ gbbdfdghy vmby{e~g(
6
E`` fmwpmh fmigv ehi idvfmwhy `dhlv e~g wp ym ieyg nwy re`di bm~ `dadygi ydag mh`t( @evy wpieygi Igfgang~, 6?
yc
>?5?_F Vmby{e~g Eirdvg~
7( _ehie Vgfw~dyt
_ehie Ehyd Rd~wv _~m >?55
Im{h`mei B~gg _ehie Ehydrd~wv _~m >?55 Y~de` Rg~vdmh M~ Kgy 5?' Hm{ db Tmw Nwt Wvdhk Fmwpmh Fmig: VF_5?MBB^55
Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~av, ~mmyldy, ehi Y~mjeh$, _ehie WVN Reffdhg#p~mygfyv WVN i~drgv b~ma ae`{e~g dhbgfydmh$, Ehyd!Vpea, _g~vmhe` Bd~g{e``, Dighydyt Ycgby_~mygfydmh, ehi ~gamyg cgw~dvydf vfehhdhk b~ma ycg f`mwi(
Vy~mhk _mdhyv
: [dyc dyv pg~vmhe` bd~g{e``, ehyd!vpea ygfchm`mkt, ehi dighydyt ycgby, ycdvpeflekg dv ycg amvy fmap`gyg nevdf rg~vdmh( Dyv 3?' ~giwfgi agam~t fmhvwapydmh b~map~grdmwv rg~vdmh aelgv dy e {m~yct fmhyghig~ bm~ Hm~ymh `dhgwp( Eh eiidydmh mb f`mwifmapwydhk nevgi p~mygfydmh eiiv ehmycg~ `etg~ ym ycg ghyd~g p~mygfydmh(
_ehie Dhyg~hgy Vgfw~dyt >?55
Im{h`mei B~gg _ehie Dhyg~hgy Vgfw~dyt >?55 Y~de` Rg~vdmh M~ K~en 5?' Idvfmwhy Hm{ Db Tmw Nwt Wvdhk Fmwpmh: VF_5?MBB^55
Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~av, ~mmyldy, ehi Y~mjeh$, _ehieWVN Reffdhg, Ehyd!Vpea, _g~vmhe` Bd~g{e``, Dighydyt Ycgby _~mygfydmh, Ehyd!_cdvcdhk,_e~ghye` Fmhy~m`, [gn Bd`yg~, Idvl Neflwp ehi ^gvym~g, ehi Mh`dhg Neflwp, ~gamygcgw~dvydf vfehhdhk b~ma ycg f`mwi, ehi b~gg >KN mh`dhg neflwp(
Vy~mhk _mdhyv
: Idvl neflwp ehi ~gvym~g bgeyw~g dv ~e~g`t vggh dh e vgfw~dyt p~miwfy( Dyvbevyg~ mpg~eydmh aelgv dy e {m~yct fmhyghig~ bm~ Hm~ymh `dhgwp( F`mwi fmapwydhkygfchm`mkt eiiv ehmycg~ `etg~ mb p~mygfydmh( Eh eiidydmhe` gsy~e >KN mh`dhg neflwp dvrg~t {g`fmag {cgh ycg mycg~ feh mh`t mbbg~ dy dh ycgd~ am~g gspghvdrg peflekg(
_ehie K`mne` _~mygfydmh >?55
Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~av, ~mmyldy, ehi Y~mjeh$, _ehieWVN Reffdhg, Ehyd!Vpea, _g~vmhe` Bd~g{e``, Dighydyt Ycgby _~mygfydmh, Ehyd!_cdvcdhk,_e~ghye` Fmhy~m`, [gn Bd`yg~, Idvl Neflwp ehi ^gvym~g, Mh`dhg Neflwp, ehi _F YwhgWp#cg`p ewymaeydfe``t bds _F p~mn`gav ehi mpydadzg vtvyga pg~bm~aehfg$(
Hg{ Bgeyw~gv
: _ehie WVN Reffdhg, ~gamyg cgw~dvydf vfehhdhk b~ma ycg f`mwi, ehi b~gg7KN mh`dhg neflwp(
Vy~mhk _mdhyv
: Idvl neflwp ehi ~gvym~g bgeyw~g aelgv ieye ~gfmrg~t b~ma ehi ym eht agide vdap`g( Dy dv ~g`den`t bevy fmhvdig~dhk dyv nw`lt peflekg( Ycg hg{ f`mwi fmapwydhkygfchm`mkt dap`gaghyeydmh dv wvgbw` dh kdrdhk p~mygfydmh b~ma hg{ ytpg mb ae`{e~g( Ycg eiidydmhe` 7KN mh`dhg neflwp dvcg`pbw` bm~ y~erg`g~v {dyc n~meinehi fmhhgfydmh(
2( Y~ghi Adf~m
Y~ghi Adf~m Ydyehdwa Ehydrd~wv, >?55
_~dfg )64(47
Im{h`mei B~gg Y~de` Rg~vdmh Y~ghi Adf~m Ydyehdwa Ehydrd~wv >?55 M~ Kgy )57 Idvfmwhy db Tmw Nwt Hm{ Wvdhk Fmwpmh Fmig: y~ghiehydrd~wv
Bgeyw~gv
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~a, ~mmyldy, ehi Y~mjeh$ ehiEhydVpt{e~g(
Vy~mhk _mdhyv
: Ycdv rg~t nevdf peflekg dv `dkcy ehi bevy
Y~ghi Adf~m Ydyehdwa Aesdawa Vgfw~dyt >?55
_~dfg )24(47
: Ehyd!Ae`dfdmwv Vmby{e~g #rd~wv, vpt{e~g, {m~a, ~mmyldy, ehi Y~mjeh$, Bd~g{e``,Iehkg~mwv [gnvdyg Igygfydmh, Ehyd Vpea, Dighydyt Ycgby _~mygfydmh, _e~ghye` Fmhy~m`, Y~ghiAdf~m Rew`y #`mflg~ bm~ fmhbdighyde` bd`gv$, >KN Mh`dhg Neflwp, ehi _F Ywhg!Wp(
Vy~mhk _mdhyv
: Nghgeyc dyv bgeyw~g!jeaagi peflekg, dy dv vyd`` `dkcy ehi bevy( Ycdv vgfw~dyt vmby{e~g {dyc vdap`dbdgi ehi gevt ym wvg dhyg~befg dv e`vm kmmi ey ~gamrdhk gsdvydhk dhbgfydmhv(
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