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Jika perdarahan sebanyak 5 ml/kgBB/jam maka perlu diberikan transfusi darah. Melakukan tindakan bedah.
Treatment of hypovolemia should be applied according to the guideline of National Institute of Health. Crystalloid first Plenty blood transfusion Treat hypothermia Red cell transfusion, if bleeding. (anticipated) Wies et al2007
FFP for a prolonged PT - The idea is to keep it 2 to 3 seconds from control, (it contains coagulation factors), each unit volume is 250ml
2-Cryoprecipitate
frozen plasma concentrate, (each bag volume is 10ml), contains 100mg fibrinogen raising f by 10mg/dl.
Transfuse platelets for platelet counts less than 20,000/mm3in active bleeding or less than 50,000 if c s is planned.
Parental vitamin k and folic acid as pt of DIC care deficient in these vitamins There is much data not in favor of use of the antifibrinolytic drugs