PEMERIKSAAN LABORATORIUM PADA ONKOLOGI

Tissa Octavira Permatasari Fakultas Kedokteran Unswagati Cirebon

Learning objectives :

Mengetahui tentang kelebihan dan kekurangan beberapa tumor marker sebagai tes diagnostik : sensitif - spesifik Mengetahui bahwa tumor marker juga dapat berperan pada kondisi non - malignant

AFP
use in liver disease, cirrhosis, hepatitis, hepatoma, teratoma and testicular tumours; knowing that AFP is normally very high in newborns; use of AFP in antenatal screening for neural tube defects and Downs syndrome

HCG
use in early pregnancy and ectopic pregnancy; use in antenatal screening for Downs syndrome; use in testicular tumours and tumours of trophoblastic origin; distinction between intact and free beta HCG.

CA 125
use in ovarian tumours; non-tumour causes of raised Ca125 (ascites, endometriosis) CA 199

use in pancreatic and gut tumours; non-tumour causes of raised Ca199 (cholangitis) CEA general marker of very low specificity and sensitivity

PSA
use in carcinoma of the prostate and benign prostatic hypertrophy (BPH); non-tumour causes of raised PSA (prostatitis); use of PSA to illustrate the overlap in PSA levels between BPH and carcinoma; bound and free PSA.