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Table Of Contents

Neuromuscular Physiology
The neuromuscular junction
Synthesis of acetylcholine
Nicotinic ACH receptor
Receptor Activation
Mechanism of Transmission
Termination of EPP
Depolarising vs non-depolarising block
Single twitch
Train of four
Non-depolarising block
Post-tetanic facilitation
Double burst stimulation
Post-tetanic count
Comparison of onset
Diaphragmatic resistance to NDMR
Onset/offset of NDMR at different muscles
Reasons for differences
Clinical implications
Onset and recovery of 4 muscles
Onset of paralysis
Surgical relaxation
Recovery
Neuromuscular Agents
Depolarising muscle relaxants
Metabolism of sux
Mechanism of action of suxamethonium
Adverse effects of sux
Hyperkalaemia and sux
Suxamethonium – side effects IOP
Suxamethonium – side effects IGP
Suxamethonium – hypersensitivity
Suxamethonium – Prolonged apnoea
Acquired Ach Enzyme Deficiency 1
Acquired Ach Enzyme Deficiency 2
Acquired Ach Enzyme Deficiency 3
Dibucaine Number
Pachy and leptocurares
DTC and MTC
Benzylisoquinoliniums
Pancuronium / Vecuronium
Vecuronium
Vecuronium / Rocuronium
Rocuronium
Cis-Atracurium
Mivacurium
Pharmacokinetic Data
Elimination
Renal Elimination
Dosages & Duration
Relative Potencies at Other Sites
Anticholinergic Agents
Typical reversal
Problems with reversal
Rocuronium and sugamamdex
Rocuronium and sugammadex
Reversal with sugammadex
Roc/sugammadex vs sux
Factors affecting onset
From site of admin to skeletal muscle capillary
From skeletal muscle capillary to NMJ
Factors increasing diffusion
Association with receptor
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Neuromuscular Blockers 2007

Neuromuscular Blockers 2007

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Published by Anaesthesia Blog

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Published by: Anaesthesia Blog on Sep 27, 2009
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10/29/2012

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