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Chlorophyll and Selenium Help Reverse Cancer, Researchers Say

Chlorophyll and Selenium Help Reverse Cancer, Researchers Say

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Published by: Dr. Robert. O. Young on Sep 29, 2009
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Chlorophyll and Selenium Help Reverse Cancer, Researchers Say
Research from the Linus Pauling Institute at Oregon State University suggests that naturalcompounds of chlorophyll, chlorophyllin, and selenium compounds, which previously have beenstudied for their ability to preventing a cancerous condition, may be able to play a moresignificant role in reversing a cancerous condition.A new study just published in the International
 Journal of Cancer 
examined the activity of chlorophyllin and found that, on a dose-by-dose basis, it was 10 times more potent at causingdeath of colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancertreatment.Beyond that, chlorophyllin kills cancer cells by blocking the same phase of cellular division thathydroxyurea does, but by a different mechanism. This suggests that it
 – 
and possibly other
“cocktails” of natural products – 
might be developed to have a synergistic effect withconventional cancer drugs, helping them to work better or require less toxic dosages, researcherssaid.
“We conclude that chlorophyllin has the potential to be effective in the clinical setting, whenused alone or in combination with currently available cancer therapeutic agents,” the researchers
wrote in their study.The concept of combining conventional or new cancer drugs with natural compounds that havebeen shown to have anti-cancer properties is very promising, said Rod Dashwood, professor anddirector of the Cancer Chemoprotection Program in the Linus Pauling Institute.
“Most chemotherapeutic approaches to cancer try to target cancer cells specifically and dosomething that slows or stops their cell growth process,” Dashwood said. “We’re now
identifying such mechanisms of action for natural compounds, including dietary agents. Withfurther research we may be able to make the two approaches work together to enhance the
effectiveness of cancer therapies.”
 Chlorophyllin is a water-soluble derivative of chlorophyll
 – 
the green pigment found in mostplants and many food products that makes possible the process of photosynthesis and plant
growth from the sun’s energy. Chlorophyllin is inexpensive, and animal studies plus human
clinical data suggest that it can be ingested at relatively high levels without toxicity.In the new study, researchers found that pharmacologic doses of chlorophyllin caused colon
cancer cells to spend more time than normal in their “synthesis phase” in which DNA is
duplicated. Timing is critical to the various phases of cell growth, researchers said, and thisdisruption started a process that ultimately led to cell death, the study found.
 
In particular, the presence of high levels of chlorophyllin caused a major reduction in the level of ribonucleotide reductase, an enzyme critical to DNA synthesis, researchers found. This is alsothe mechanism of action of hydroxyurea, one drug already being used for cancer chemotherapy.
“In cancer research right now there’s interest in approaches that can reduce ribonucleotidereductase,” Dashwood said. “At the dos
es used in our experiments, chlorophyllin almost
completely stops the activity of this enzyme.”
 Further research is needed both in laboratory and animal studies, with combinations of chlorophyllin and existing cancer drugs, before it would be appropriate for human trials,Dashwood said. Chlorophyllin, in general, is poorly absorbed from the human gastrointestinal
tract, so it’s unclear what levels might be needed for therapeutic purposes or how well they
would work.Other dietary agents also might have similar potential. Work just published by LPI researchers inthe journals Carcinogenesis and Cancer Prevention Research explored the role of organicselenium compounds in killing human prostate and colon cancer cells. Colorectal and prostatecancers are consistently among the leading causes of cancer mortality in the United States, andwill account respectively for 18 percent and 9 percent of all cancer deaths in 2009, according toestimates from the American Cancer Society.In the recent studies, a form of organic selenium found naturally in garlic and Brazil nuts was
converted in cancer cells to metabolites that acted as “HDAC inhibitors” – 
a promising field of research in which silenced tumor suppressor genes are re-activated, triggering cancer cell death.
“Whether it’s HDAC inhibition leading to one manner of cancer cell growth arrest, or loss of ribonucleotide reductase activity leading to another, as seen with chlorophyllin, there’s
significant promise in the use of natural products for combined cancer ther
apies,” Dashwoodsaid. “These are areas that merit continued research.”
 These studies were supported by the National Cancer Institute and the National Institute of Environmental Health Sciences. Other collaborators included researchers from the New York Medical College and the Penn State College of Medicine.Chlorophyll is identical to your hemoglobin except for the center atom. Dr. Robert O. Young's,at the pH Miracle Living Center in San Diego, California suggests, "as one increases theirconsumption of chlorophyll from green foods and green drinks the quality and quantity of the redblood cells improve. This can be noted on a CBC medical test as the red blood cell countincreases and the hemoglobin increases to a healthy range. Liquid chlorophyll and chlorophyllincan be added to any water or green drink to improve the concentration of this powerful bloodbuilding compound."http://www.phmiracleliving.com/p-306-liquid-chloropheal-4-oz.aspx
 
References: Chlorophyll and Chlorophyllin
1. Matthews CK, van Holde KE. Biochemistry. 2nd ed. Menlo Park: The Benjamin/CummingsPublishing Company; 1996.2. Sudakin DL. Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review. JToxicol Clin Toxicol. 2003;41(2):195-204. (PubMed)  3. Dashwood RH. The importance of using pure chemicals in (anti) mutagenicity studies:chlorophyllin as a case in point. Mutat Res. 1997;381(2):283-286. (PubMed)  4. Egner PA, Stansbury KH, Snyder EP, Rogers ME, Hintz PA, Kensler TW. Identification andcharacterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllinchemoprevention trial. Chem Res Toxicol. 2000;13(9):900-906. (PubMed)  5. Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. Mechanisms of the invitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition,molecular complex formation and degradation of the ultimate carcinogen. Mutat Res.1994;308(2):191-203. (PubMed)  6. Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes betweenchlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-218.(PubMed) 7. Breinholt V, Schimerlik M, Dashwood R, Bailey G. Mechanisms of chlorophyllinanticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chem ResToxicol. 1995;8(4):506-514. (PubMed)  8. Egner PA, Munoz A, Kensler TW. Chemoprevention with chlorophyllin in individualsexposed to dietary aflatoxin. Mutat Res. 2003;523-524:209-216. (PubMed)  9. Kumar SS, Devasagayam TP, Bhushan B, Verma NC. Scavenging of reactive oxygen speciesby chlorophyllin: an ESR study. Free Radic Res. 2001;35(5):563-574. (PubMed)  10. Kamat JP, Boloor KK, Devasagayam TP. Chlorophyllin as an effective antioxidant againstmembrane damage in vitro and ex vivo. Biochim Biophys Acta. 2000;1487(2-3):113-127.(PubMed)11. Park KK, Park JH, Jung YJ, Chung WY. Inhibitory effects of chlorophyllin, hemin andtetrakis(4-benzoic acid)porphyrin on oxidative DNA damage and mouse skin inflammationinduced by 12-O-tetradecanoylphorbol-13-acetate as a possible anti-tumor promotingmechanism. Mutat Res. 2003;542(1-2):89-97. (PubMed)  12. Kumar SS, Shankar B, Sainis KB. Effect of chlorophyllin against oxidative stress in spleniclymphocytes in vitro and in vivo. Biochim Biophys Acta. 2004;1672(2):100-111. (PubMed)

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