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Physicochemical Properties in Relation to Biological Activity

Physicochemical Properties in Relation to Biological Activity

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Published by: jemms16 on Sep 29, 2009
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02/26/2014

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PhysicochemicalProperties in Relationto Biological Activity
YanZhang, Ph.D.Department of Medicinal Chemistryyzhang2@vcu.edu
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A. Drug Distribution and PharmacologicalResponse
Drug in formulationDeggregation,dissolutionDrug in solutionDrug in bloodabsorption across membrane
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1. Absorption
pH values in each part of ourGI tract:Stomach: 1-3Small Intestine: ~7large Intestine: 7-8
 
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2. Protein Binding
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3. Membrane Structure
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PhospholipidMolecule
The uniquechemicalstructure ofphospholipidmoleculedecides thecharacter of themembranearchitecture.
 
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Passive Diffusion
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Active Transport
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4. Distribution and Excretion
After the absorption,some drugmolecules will act ontarget site, some maybe metabolized.Eventually all thedrug moleculeswould be excretedfrom our body.

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