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Metabolism
Lactate and Metabolic Acidosis
Lactate and Metabolic Acidosis
Production of Lactate
pyruvate + NADH +
pyruvate + NADH +H
H+
+
\u2190\u2192
\u2190\u2192
lactate
lactate + NAD
+ NAD+
+
sSo, how does a reaction, which actually
So, how does a reaction, which actually
consumes a hydrogen ion
consumes a hydrogen ioncause
cause a metabolic
a metabolic
acidosis ?
acidosis ?
Lactate
sNAD
NAD+
+ is necessary for the conversion of
is necessary for the conversion of
phosphoglyceraldehyde to 3-
phosphoglyceraldehyde to 3-
phosphoglycerate
phosphoglycerate
straditional teaching is that under
traditional teaching is that underanaerobic
anaerobic
conditions, this NAD
conditions, this NAD+
+ is supplied by the
is supplied by the
above reaction,
above reaction,allowing
allowing glycolysis to
glycolysis to
continue
continue
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