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Isotonic Calculation

# Isotonic Calculation

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isotonic calculation with blood and tear
http://www.slideshare.net/mlkn/isotonic-calculation
isotonic calculation with blood and tear
http://www.slideshare.net/mlkn/isotonic-calculation

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05/27/2013

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~mlk~
| 1
Freezing Point Depression Method
CALCULATION FOR SOLUTION ISOTONIC WITH BLOOD AND TEARS
Some of the many ways;1.

Freezing point depression method2.

NaCl equivalent method3.

White Vincent method4.

Sprowl method5.

Molecules concentration method6.

Graphical method on vapor pressure and freezing point determination
1.

FREEZING POINT DEPRESSION METHOD

The plasma and blood freezing point temperature = -0.52°C

The dissolved substances in plasma or tear depress the solution freezing point below 0.52°C

Any solution that freeze at T=-0.52°C is isotonic with blood and tear

weight of substance that need to be adjusted to make it hypotonic given by the followingformula;
=0.52−
Where,W=the weight, in g, of the added substance in 100ml of the final solutiona =the depression of the freezing point of water produced by the medicament already in thesolution (calculated by multiplying the value for b for the medicament by the strength of thesolution express as % w/v)b=the depression of freezing of water produced by 1 per cent w/v of the added substance

~mlk~
| 2
Freezing Point Depression Method
Example 1.1Solution;
=
.
=
.(
.
×.).

=4.12   100 
For 500ml;
=(4.12 )×500100

=20.6  
Example 1.2RxEphedrine HCl 1gChlorobutol 0.5gNaCl (1.4g) q.sDistilled water q.s ad 200mlSolution;
=0.52−=0.52−[(0.5×0.165)(0.25×0.138)]0.576

=0.7    100 

 200
;
=(0.7 )×200100

=1.4  
Rx ∆Tf 1%NaCl 900mg 0.576Dextrose q.s (20.5g) 0.101 Ft. isotonic soulution500ml

0.9%500= 100

=0.18%
Or;

~mlk~
| 3
Freezing Point Depression Method
EXercise 1.3Prepare 500ml NaHCO
3
(∆T.f 1%=0.38) so that when it is dilute with the same amount of water, it wouldbe isotonic.Solution;Rx ∆T.f 1%NaHCO
3
Xg(13.7) 0.38Water qs ad 500mlThe solution is hypertonicWhen dilutedNaHCO
3
XgWater qs ad 1000mlThis solution is isotonic
=0.52−=0.52−00.38=1.37 ℎℎ  
NaHCO
3
required to make the solution isotonic upon dilution is;
1.37100=
χ
1000
1.37 X 10 = 13.7g (to be dissolved to 500ml solution)