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Table Of Contents

OPEN MEETING
I am a professor in the Department of Environmental and Molecular
Toxicology at North Carolina state University. My area of research
Endocrinology at the University of Berlin. I'm also head of the
Department of Inland Fisheries at the Institute for Freshwater
Ecology and Inland Fisheries. My expertise is in endocrine disruption
Entomology at Iowa state University. I'm a professor of Entomology-
DR. DENVER: I'm Robert Denver. I'm an Associate Professor
DR. RICHARDS: I'm Carl Richards. I'm a Professor of
Minnesota Sea Grant College Program. My expertise is in the general
DR. DELORME: My name is Peter Delorme. I'm a Senior
Pesticide Researcher with the Canadian Government with the Pest
Management and Regulatory Agency. My area of expertise is in
Ecology at Yale University. My area of expertise is population and
DR. MATSUMARA: I'm Dr. Matsumara. I'm a Professor of the
Environmental Toxicology. I also run the program called "The Center
DR. THRALL: I'm Mary Anna Thrall. I'm a Professor in the
Ecology of Veterinary Medicine and Biomedical Sciences at Colorado
State University. My area of expertise is veterinary clinical
Department of Chemistry and molecular pharmacology at Perdue
Director of the Statistical Design Group at the Institute for Social
Research at the University of Michigan. I'm a biostatistician and my
Professor in the Departments of Physiological Sciences and
Pharmacology and Therapeutics and also a Director of the Center for
Good morning Dr. Bradbury
Novartis. Novartis and Zeneca Chemical Businesses merged and
Peter Pan Rats. They just fail to sexually mature. They stay as young
We're not aware of the weights of the Hayes animals. Body weight
Gould. You must read the book. He makes this point. The
DHP. It is essentially did same data -- there are differences between
Christa and Tim gave and Rebecca rana from the Environmental
DR. ASHBY: Right
DR. KELLEY: Thank you
DR. ROBERTS: Dr. Green
DR. ASHBY: It must be
DR. LEBLANC: Agreed
DR. ROBERTS: Dr. Isom
DR. ROBERTS: Dr. Delorme
DR. DELORME: Agreed
DR. ROBERTS: Dr. Kelley
DR. KELLEY: Could I raise a question?
DR. BRECKENRIDGE: Good morning ladies and gentlemen. I
DR. ROBERTS: Thank you Dr. Breckenridge
I believe Dr. Denver has a question for you
DR. BRECKENRIDGE: We have not attempted to repeat them
They appear to be substantial and clear. That is to say the DOS
DR. BRECKENRIDGE: As a bioassay for the presence of
DR. BRECKENRIDGE: Thank you
Dr. Isom and next and Dr. Skelly and Dr. Kloas
DR. ISOM: Thank you
DR. BRECKENRIDGE: I'm not aware of those studies as it
DR. BRECKENRIDGE: Yes. My view on invitro versus invivo
DR. BRECKENRIDGE: We looked long and hard for inducer of
DR. BRECKENRIDGE: I find it interesting the concept of
DR. ROBERTS: Dr. Skelly
The suggestion by Dr. Ashby that maybe the way to go -- the priority
DR. ROBERTS: Dr. Kloas
DR. BRECKENRIDGE: Thank you very much for that question
DR. KLOAS: It's Luetz and Lewis (ph) in 1999
DR. BRECKENRIDGE: Thank you very much for those
DR. BRECKENRIDGE: Thank you very much for that
Welcome Dr. Hayes
Director of the Laboratory for Integrated Studies in Amphibian
The point I'm going to make I'm here -- I'm going to show you several
I think it was Dr. Vandercrack (ph) stated yesterday that if we know
Ecorisk. We used to do renewal everyday. We do three-day static
DR. KELLEY: You mean viability?
DR. HAYES: Viability. I'm sorry
I should point out this work was done while I was part of the Ecorisk
PNAS. One of the things that will become clear at the end of my talk
Narvata Syngenta Ecorisk Panel. That was done in -- began in 1988
DR. KELLEY: Which replicate are these data from?
DR. HAYES: Two and three? Yes
DR. KELLEY: You just described it?
DR. HAYES: Yes
DR. KELLEY: They look different
DR. KELLEY: There's definitely more than ten
DR. HAYES: It was more than ten. I apologize
DR. HAYES: I can go back and give you that number exactly
section
DR. ROBERTS: Dr. Denver
DR. ROBERTS: Dr. LeBlanc
DR. LEBLANC: This is not what we're looking at here?
DR. LEBLANC: Is it included in here?
DR. LEBLANC: Thank you
DR. ROBERTS: Any other questions?
DR. LEBLANC: Is there any incident in the controls?
DR. LEBLANC: It is higher level?
DR. HAYES: I would have to double check. I can't --
DR. HAYES: What time is it now?
DR. ROBERTS: That would be another 20 minutes
DR. ROBERTS: Yes
Dr. Kelley and then Dr. Denver
DR. HAYES: Thank you
4 DR. HAYES: That's three tanks with 30 animals in each
5 That's been done one time in the Syngenta study. There are two
6 studies published in the PNAS. There is animals that were sampled
8 DR. DENVER: Right. I'm not asking about the number of
12 DR. HAYES: In -- no. In the animals that we move out in
20 DR. HAYES: When we do --sorry
DR. HAYES: Those are the ones I showed there
Wisconsin. These are the animals that were reported in the Nature
Paper and in Environmental Health Perspective Paper. I'm going
Perspective Paper. Most of the animals were not identifiable as
section is testicular. I'll blow it up for you. This section is clearly
This is not part of EPA taping the meeting or anything like that
I'm working now with William Battaglin. We're sampling in these
Syngenta Ecorisk studies where one time measurements. Even
EPA numbers show up on this government document. It shows up
Apparently they all have it. It's a symbion. But they don't succumb
We measure it over time to make sure it's stable. USGS has been
DR. ROBERTS: Dr. Skelly?
He got us permission. Fred Jasen is his name. I think he is
DR. HAYES: No. I did not. No
We would get out and walk and look for frogs. It's the same way I
DR. ROBERTS: Dr. Heeringa
DR. HEERINGA: No
DR. ROBERTS: Dr. Kloas and Dr. Denver
DR. ROBERTS: Dr. Denver?
DR. HAYES: Yes. You will see more of that today
DR. HAYES: Yes. Those are published in the EHP paper
DR. COATS: Yes
DR. COATS: Okay
DR. HAYES: Only the water
DR. HAYES: Uh-huh (Affirmative)
DR. HAYES: We have done that also
DR. KELLEY: So you have that
DR. HAYES: Sorry. I misspoke
DR. GREEN: It is actually an opportunistic pathogen
DR. HAYES: He has joined my laboratory for his Ph.D
DR. GREEN: I didn't know that
DR. KLOAS: I'm just referring to the adult samples
DR. KLOAS: So it's androgens in general probably
DR. HAYES: Yes. That's correct
DR. KLOAS: I'm sorry for that. It should be present --
DR. KLOAS: At least it should be measurable
DR. HAYES: I will address that. I have some more data
DR. KLOAS: Thank you
DR. ROBERTS: Dr. Skelly and then Dr. LeBlanc
DR. HAYES: Sorry. Say again
DR. HAYES: Will I try to assess --
DR. HAYES: That's right
DR. ROBERTS: Dr. Gibbs
DR. GIBBS: Thank you
DR. HAYES: I'll be quick
What I'm going to do is I'm going to talk briefly about each one and
And I do believe that that is the case. So we're probably
USGS and I have shown that every three days the amount of atrazine
University of Berkeley endocrinologist Tyrone Hayes' hypothesis that
Texas Tech and Jim Carr and Tim Gross and everybody was in
You should recognize that. That's a gonad. That's a larynx. And in a
That's the only compound I have ever treated with when I find these
DR. GREEN: What is the food?
DR. HAYES: That may have been my oversight
DR. HAYES: Not necessarily
What is the half life? How long would the estrogen stay around? You
DR. ISOM: What I tissue would you recommend to look at?
DR. ROBERTS: Dr. Matsumura
DR. MATSUMURA: What do you think?
DR. HAYES: Sorry. That wasn't from the PNAS paper. Those
DR. COATS: Are those data available?
DR. HAYES: It goes down by 30 percent
DR. HAYES: No. We looked at atrazine and --
1 DR. COATS: At what concentration?
5 DR. COATS: The graph you showed us about the maturation
8 DR. HAYES: Which?
11 DR. HAYES: That's the .1. Anything higher than that died
13 DR. COATS: Not of the 10 mixture. Just of the atrazine and
15 DR. HAYES: That's .1
16 DR. COATS: Thank you
19 To what extent are your data available to EPA as they try and
DR. ROBERTS: Thank you
Dr. LeBlanc and then Dr. Denver and Dr. Green
DR. HAYES: Absolutely
DR. GREEN: Thank you
DR. KELLEY: Right. And where does vitellogenin come from?
DR. HAYES: Comes from the liver
DR. ROBERTS: Dr. Heeringa and then Dr. Coats
DR. HEERINGA: Thank you
DR. ROBERTS: Dr. Coats
DR. COATS: Just a comment on the flow through possibilities
DR. COATS: Just wondering
DR. ROBERTS: Thank you very much
Any other questions for Dr. Hayes?
DR. HAYES: Thank you for the opportunity
Ecorisk panel has performed are available to the EPA. They were
EPA. And there was a lot going on. I had 12 or 13 different studies
DR. HAYES: If I could share what?
DR. SKELLY: Share the paper
EPA involving my involvement. But I don't know if I can give you
DR. ROBERTS: Maybe we can ask a representative --
I think Dr. Sielkin is here perhaps to answer that question?
DR. HAYES: I sent it back to you twice
DR. HAYES: I've got a Fedex receipt
DR. MCFARLAND: I'm Janice McFarland with Syngenta. All
DR. KELLEY: I'll check my CD. But it wasn't in the printout
DR. HAYES: My pleasure
Is Mr. Slaughter here?
DR. HAYES: I'll be in Brazil next week
MR. SLAUGHTER: Leave a number
DR. DUGAN: Thank you
Coordination and Policy and others who are involved in the EDM
DDT. Kind of brings me back to my earlier days in the 60s when
There are confounding conclusions to be drawn. I guess I almost
Now I ask for Stephanie Whalen to speak first
But on the CD I could not find the feeding data. If you could provide
2002. The statistical report that Dr. Sielkin discussed with Dr. Hayes
DR. KELLEY: Okay. Thank you
MR. HEDBERG: Yes
MR. HEDBERG: I would certainly appreciate that
DR. HEDBERG: Very good. Thank you
PTROS or any of the data that were attached to the final report. I will
CERTIFICATE OF STENOTYPE REPORTER
I-N-V-O-I-C-E*** ***I-N-V-O-I-C-E***
TODAY'S DATE: 6/30/03
DATE TAKEN: 6/18/03
CASE NAME: FIFRA conference
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TOTAL: PAGES: 547, plus 105 pgs OT
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Environmental Protection Agency: 061803transcript

Environmental Protection Agency: 061803transcript

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Published by: Environmental Documents on Feb 05, 2008
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