STABILITAS OBAT

Case
Members:
Rieneke Eoudia Han
Hairunisa
Desy Ratnasari
Utin Nur Kharunisa
Dini Sepkawila Caturizani
Windy Tri Agusta

Log

Waktu
(min)

Amoksisilin

N-benzoiamoksisilin

40C

50C

60C

70C

40C

50C

60C

70C

30

-2,125 x
102

-2,138 x
102

-2,504 x
102

-2,689 x
102

-1,902 x
102

-3,935 x
102

-4,799 x
102

-6,006 x
102

60

-3,297 x
102

-4,368 x
102

-5,636 x
102

-1,403 x
101

-4,495 x
102

-7,667 x
102

-1,295 x
101

-1,336 x
101

90

-4,272
x 102

-7,598 x
102

-1,399 x
101

-3,188 x
101

-7,841 x
102

-1,211 x
101

-2,058 x
101

-2,337 x
101

120

-5,125 x
102

-1,013x
101

-1,799 x
101

-4,823 x
101

-1,013 x
101

-1,765 x
101

-2,836 x
101

-3,337 x
101

150

-6,069 x
102

-1,133 x
101

-3,057 x
101

-6,845 x
101

-1,441
x101

-2,183 x
101

-3.583 x
101

-4,572 x
101

Pers.
Reg

Y=Y= Y= Y= 1,021.
1,525.
2,591.
3,314.
103 x - 103 103 103
1,439. + 1,093. + 2,764. + 1,481.
102
102
102
101

AMOKSISILIN
Log

kt = - Log

2,303

x 2,303

T= 40C
b = - 3,238 x 104
kt = -(-3,238. 104 ) x 2,303
k (1) = 7,457 x 104
k = 7,457 x 104

Log

T= 50C
b = - 8,048 x 104
kt = -(-8,048. 104 ) x 2,303
k (1) = 1,854 x 103
k = 1,854 x 103

AMOKSISILIN
T= 60C
b = - 2,282 x 103
kt = -(- 2,282.103 ) x 2,303
k (1) = 5,257 x 103
k = 5,257 x 103
T= 70C
b = - 5,524 x 103
kt = -(- 5,524. 103 ) x 2,303
k (1) = 1,272 x 103
k = 1,272 x 103

AMOKSISILIN
T= 40C
k = 7,457 x 104
1 2 =

1 2 =

T= 50C
k = 1,854 x 103

ln 2

0,693
7,457 104

1 2 = 929,328

1 2 =

1 2 =

ln 2

0,693
1,854 103

1 2 = 373,786

1 2 =

ln 2

1 2 =

0,693
5,257 103

1 2 = 131,824

k = 1.272 x 103

T= 50C
1 2 =

T= 60C
k = 5,257 x 103

ln 2

1 2 = 54,481

0,693
1,272 103

N-BENZOILAMOKSISILIN
Log

kt = - Log

2,303

x 2,303

T= 40C
b = -1,021x103
kt = -(-1,021x103 ) x 2,303
k (1) = 2,352 x 103
k = 2,352 x 103

Log

T= 50C
b = -1,525 x 103
kt = -(-1,525 x 103 ) x 2,303
k (1) = 3,512 x 103
k = 3,512 x 103

N-BENZOILAMOKSISILIN

T= 60C
b = - 2,591.103
kt = -(- 2,591.103 ) x 2,303
k (1) = 5,967 x 103
k = 5,967 x 103
T= 70C
b = - 3,314 x 103
kt = -(-3,314 x 103 ) x 2,303
k (1) =7,632 x 103
k = 7,632 x 103

N-BENZOILAMOKSISILIN

T= 40C
k = 2,352 x 103
1 2 =

1 2 =

T= 50C
k = 3,512 x 103

ln 2

0,693
2,352 103

1 2 = 294,517

1 2 =

1 2 =

ln 2

0,693
3,512 103

1 2 = 197,323

1 2 =

1 2 =

ln 2

1 2 = 90,801

0,693
7,632 103

ln 2

0,693
5,967 103

1 2 = 116,529

k = 7,632 x 103

T= 50C
1 2 =

T= 60C
k = 5,967 x 103

RESULT
Maka, didapatkanlah nilai amoksisilin dan
N-benzoilamksisilin pada suhu 40C, 50C, 60C dan
70C seperti yang tertera di jurnal pada tabel 6.

The End
Any Questions????