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Drug Phenytoin

Drug Phenytoin

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Published by Salman

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Published by: Salman on Oct 16, 2009
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12/29/2012

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UNIVERSITY COLLEGE OF PHARMACYDRUG PROFILE
Drug Name (Generic) PHENYTOIN
1.
PRODUCT DESCRIPTION
Sr.No.Manufacturer’sProprietary NameDosage FormAmount oactiveIngredientsStorageConditions
1
Dilantin®
(extended phenytoinsodium)Pfizer Capsules, USP30 mg or 100 mg phenytoinsodium, USP.Store atcontrolled roomtemperature.Preserve in tight,light-resistantcontainers.Protect frommoisture.
2
Di-hydanFrenchTablets100mgStore atcontrolled roomtemperature.Preserve in tight,light-resistantcontainers.Protect frommoisture.
3
EpilantinPharmedicSuspensionTablets300mg/5ml30mgStore in theoriginal packagein order to protectfrom light. Donot store above25°C.
4
EpitoinAdamjeeCapsules100mgStore in theoriginal packagein order to protectfrom light. Donot store above25°C.
5
Epanutinparenteral250mg/5mlDo not store
 
 
Pfizerabove 25°C Onceopened, useimmediately anddiscard anyunused contents.
2.
CHEMISTRY OF PRODUCT
ChemicalClassStructureNaturePhysical Properties
HydantoinDerivativesodium 5,5-diphenyl-2, 4-imidazolidinedioneHydantoin saltWhite crystalline powder or granule. Non taste. non smell
Solubility
o
Acetone,Ethanol :slightlysoluble
o
Chloroform,Ether : hardlysoluble
o
Water : almostinsoluble
3.
BIO-PHARMACEUTICS
i.
ABSORPTIONDosage FormRoute of AdministrationSite of Absorption
TabletsOralCompletely absorbed fromGIT
ii.
DISTRIBUTIONBio-availability%ProteinPlacental Barrier BloodBrainBarrier Volume of DistributionTime for peak bloodlevelsTherapeutic
70-100% oral, 90% CrossesCrosses0.52 and 1.19 1.5-3hrs for 10-20
 
 
24.4% for rectal andintravenousadministration protein binding inadultslitres/kgprompt release& 4 to 12 hrsfor extendedreleaseadministration.mcg/mL
iii.
ELIMINATIONElimination Half LifeSite of MetabolismMetabolite(s)Route of Excretion
22hoursOxidized in liverParahydroxyphenylderivative; InactivemetabolitesPrimarily through the bile, urinary
4.
CLINICAL PHARMACOLOGY
TherapeuticClassPharmacologicalClassMechanism of ActionActivity oMetabolite(s) (if any)
AnticonvulsantsAnti-epilepticsThe mechanism by which phenytoin exerts itsanticonvulsant action hasnot been fully elucidatedhowever, possiblecontributory effectsinclude:1. Non-synaptic effects toreduce sodiumconductance, enhanceactive sodium extrusion, block repetitive firing andreduce post-tetanic potentiation2. Post-synaptic action toenhance gaba-mediatedinhibition and reduceexcitatory synaptictransmission3. Pre-synaptic actions toreduce calcium entry and block release of neurotransmitter. No

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