Professional Documents
Culture Documents
By
Dr Bashir Ahmed Dar
Chinkipora Sopore
Kashmir
Associate Professor
Medicine
Email
drbashir123@gmail.com
From Right to Left
Dr.Smitha associate
prof gynae
Dr Bashir associate
professor Medicine
Dr Udaman
neurologist
Dr Patnaik HOD
ortho
Dr Tin swe aye paeds
From RT to Lt
Professor Dr Datuk
rajagopal N
Dr Bashir associate
professor medicine
Dr Urala HOD
gynae
Dr Nagi reddy
tamma HOD-
opthomology
Dr Setharamarao
Prof ortho
INFECTIVE ENDOCARDITIS
A microbial infection of the endothelial
lining of the heart; most commonly
occurring as a vegetation on the valve
leaflets
INFECTIVE ENDOCARDITIS
Annual incidence: Age Distribution
15,000 to 20,000 60%
Forth leading cause of 50%
40%
life-threatening 30%
•70% streptococcal
• 20% staphylococcal
Predisposing factors
Neutropenia
&
Immunosupression
PREDISPOSING FACTORS
Staph aureus accounts for the majority of
cases of endocarditis in case of IV drug
abusers and is recurrent polymicrobial
tricuspid valve, either alone or in
combination, is most often infected
PREDISPOSING FACTORS
Moderate risk
– patent ductus arteriosus
– VSD, primum ASD
– coarctation of the aorta
– bicuspid aortic valve
– hypertrophic cardiomyopathy
– acquired valvular dysfunction
– MVP with mitral regurgitation
PREDISPOSING FACTORS
Low risk
– isolated secundum atrial septal defect
– ASD, VSD, or PDA >6 months past repair
– “innocent” heart murmur “
PREDISPOSING FACTORS
INVASIVE PROCEDURES
– G.I.
Barium enema
Colonoscopy
– Genitourinary
Prostatectomy
PREDISPOSING FACTORS
INVASIVE PROCEDURES
Tooth extraction
Periodontal surgery
Teeth cleaning
Tooth brushing, flossing
Using wooden
toothpicks
Chewing food
PREDISPOSING FACTORS
INVASIVE PROCEDURES
Biopsies,suture
removal, placing
orthodontic bands
Tonsillectomy,Adenoid
ectomy,Bronchoscopy.
Resp tract procedure to
drain abscess or
empyema
PREDISPOSING FACTORS
INVASIVE PROCEDURES
Central venous
catheterization
Bladder catheterization,
Endoscopies, shaving,
Skin or
musculoskeletal
infections
PREDISPOSING FACTORS
– AIDS patients
– Cancer patients
– Leukemia
– Lymphomas
MICROBIAL AGENTS
RESPONSIBLE FOR IE
The commonest cause is Then is enterococci
streptococci (alpha
hemolytic) and constitutes 10%
about 70%.among which And other streptococci
Streptococci viridans is 35%
that reside in oral cavity 10%
along with HACK associated
with dental procedures.
Then is streptococcus bovis
that resides in oral &
colon.colonic cancers 15%
MICROBIAL AGENTS
RESPONSIBLE FOR IE
Staphylococcus aureus: Prosthetic valve
healthy or deformed valves, endocarditis also occurs
esp. in intravenous drug
abusers and prosthetic
by Candida and
valves. aspergillosis but form
Prosthetic valve large vegetations.
endocarditis during the
perioperative period or
60 after operation also
by s.epidermitides.
MICROBIAL AGENTS
RESPONSIBLE FOR IE
Stick in Perforation
Mitral Valve
Endothelial damage
Platelet-fibrin thrombi
Microorganism adherence
Summary of
Pathogenesis BE
Turbulent blood flow (from congenital or
acquired heart dz)Endothelial trauma
Platelets and fibrin deposit on damaged
endothelium Nonbacterial Thrombotic
Endocarditis (NBTE)
Bacteremia Colonization of NBTE
Bacterial Vegetation
THINGS TO REMEMBER IN
INFECTIVE ENDOCARDITIS
Infective endocarditis affects
versus
Cough 25%
Sweats 25%
Anorexia 25%
Weight loss 25%
Malaise 25%
Skin lesions 20%
Nausea/vomiting 20%
Stroke 20%
CLINICAL FEATURES OF
ENDOCARDITIS
More Uncommon Symptoms
Headache 15%
Myalgia/arthralgia 15%
Edema 15%
Chest pain 15%
Abdominal pain15%
Delirium/coma 15%
Back pain 10%
Hemoptysis 10%
CLINICAL FEATURES OF
ENDOCARDITIS
Common Physical Signs
Fever 90%
Heart murmur 85%
Splenomegaly 30%
Petechiae 30%
CLINICAL FEATURES OF
ENDOCARDITIS
Uncommon Physical Signs
Janeway lesions 5%
(small palm/sole hemorrhages)
Anemia 80%
Proteinuria 60%
LABORATORY FINDINGS
Laboratory Findings
Transesophageal(TEE) echocardiography
>90% sensitivity for vegetations
Requires 2 major,
or 1 major + 3 minor
or 5 minor criteria
Duke’s Major Criteria
Major Criteria
1. Positive blood culture
– typical microorganism (strep viridans, strep bovis,
HACEK group, staph aureus or enterococci in the
absence of a primary locus) for endocarditis from two
separate blood cultures
– persistently positive blood culture from:
blood cultures drawn more than 12 hr apart, or
all of 3 or a majority of 4 or more separate blood cultures, with
first and last drqwn at least 1 hr apart
Duke’s Major Criteria
Myocardial abscess20%
Glomerulonephritis15%
(immune complexes)
“Mycotic aneurysm” 10%
Pericarditis (S.aureus) rare
INDICATIONS FOR
PROPHYLAXIS
Prophylaxis is indicated for
Prosthetic heart valves
Congenital heart disease with manifestations
Acquired heart disease with manifestations
Hypertrophic cardiomyopathy
Mitral valve prolapse with regurgitation
Previous history of endocarditis
Dental procedures known to produce bleeding
Surgery involving GI, respiratory mucosa
INDICATIONS FOR
PROPHYLAXIS
Tonsillectomy
Esophageal dilation
ERCP for obstruction
Gallbladder surgery
Cystoscopy, urethral dilation
Urethral catheter if infection present
Urinary tract surgery
Tonsillectomy
Rigid bronchoscopy.
INDICATIONS FOR
PROPHYLAXIS
Esophageal sclerotherapy or stricture dilation
Respiratory: Consider if pt will be cut or biopsied
Periodontal procedures (surgery, scaling, and root
planing, probing, and recall maintenance)
Implant placement and reimplantation of avulsed
teeth
Endodontic instrumentation beyond the apex
Subgingival placement of antibiotic fibers or strips
Placement of orthodontic bands but not brackets.
INDICATIONS FOR
PROPHYLAXIS
ERCP
Billiary surgery
Prostate surgery
Cystoscopy
Cardiac transplants
Extractions of teeth
Intraligamentary injections
Prophylactic cleaning of teeth or implants where
bleeding is anticipated
No Prophylaxis
Vaginal delivery Radiographs
Hysterectomy Orthodontic adjustments
Shedding of primary teeth
Local anesthetic injections
IUDs
Placement of oral rubber Circumcision
dams MVP without regurgitation
Post-op suture removal Pacemakers but see if not
Placement of removable already infected
appliances Physiologic murmurs
Fluoride treatment
Indications for Surgery
(When removal of an infected valve is necessary).
Refractory CHF
Severe valvular dysfunction
Uncontrolled infection
Valve perforation
Dehiscence
Fistula
Abscess
Indications for Surgery
Embolic event with persistent large vegetation
or >1 episode of embolization
Prosthetic valve infection
Fungal IE
New heart block
Refractory CHF
Uncontrolled infection
Ineffective antimicrobial therapy
Indications for Surgery
Resection of mycotic Large (>1cm diameter)
aneurysms
anterior mitral valve
antibiotic-resistant pathogens)
vegetation
Local suppurative
complications including Acute mitral insufficiency
perivalvular or myocardial
abscesses
Valve perforation or
Persistent vegetations after a rupture
major systemic embolic Increase in vegetation size
episode 4 weeks after antibiotic
therapy
Indications for Surgery
Periannular extension of Unresponsive
infection infection/ continued
Infected prosthetic infection despite
material: less than 1 year appropriate antibiotics
out from original heart
surgery
Refractory congestive
heart failure (Leading
cause of death)
Indications for Surgery
Pt. experiences more than Persistent bacteremia
1 major emboli Acute AR or MR with
Severe valvular heart failure.
dysfunction: Acute CHF
or impaired hemodynamic
Acute AR with
status tachycardia and early
Relapsing prosthetic valve closure of the MV.
endocarditis Annular or aortic abscess.
Fungal endocarditis Sinus or aortic aneurysm.
New conduction defects or Persistent bacteremia and
arrhythmias valve dysfunction
Indications for Surgery
Recurrent emboli after Increase in vegetation
appropriate Abx. size after antimicrobial
Mobile vegetations therapy
>10 mm. Valvular dysfunction
Persistent pyrexia and Fungal endocarditis
leucocytosis with
negative blood
cultures.
TREATMENT OF INFECTIVE
ENDOCARDITIS
Purpose of Prophylaxis
To give antibiotics and kill blood-borne bacteria
or interfere with their metabolism, hindering their
ability to adhere to a damaged heart valve.
However antibiotic resistance is increasing. Only
administered prior to “high risk” surgeries Include
dental procedures, surgery on the gastrointestinal
or urinary tract, surgery on infected tissues
TREATMENT OF INFECTIVE
ENDOCARDITIS
50% of some valvular infections do not respond
to antimicrobial therapy or surgery
Today’s highly virulent causative agents have
led to an increase in dangerous complications