Antiasthmatic & COPD Preparations
Bronchial asthma & pulmonary disease w/ spastic bronchial component.
Mechanism of action:
Adrenergic bronchodilators and phosphodiesterase inhibitors bothwork by increasing intracellular level of cyclic-3’,5’- adenosine monophosphate(cAMP); adrenergics by increasing production and phosphodiesterase inhibitors by decreasing breakdown. Increased levels of cAMP produce bronchodilation.Corticosteroids act by decreasing airway inflammation. Anticholinergics(ipratropium) produce brondhodilation by decreasing intracellular levels of cyclic guanosine monophosphate (cGMP). Leukotriene receptor antagonists andmast cell stabilizers decrease the release of substances that can contribute to bronchospasm.
Adult 1 tab bid- tid.
Children >12 yr 10 mL once- tid, <12 yrs 6-9mg/kg bid.
Acute MI, hypotension, lactation
Liver disease, CHF, chronic obstructive lung disease, concomitantinfections. Pregnancy.