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Brand Name: Ansimar Generic Name: Doxofylline Drug Classification: Antiasthmatic &

Brand Name: Ansimar Generic Name: Doxofylline Drug Classification: Antiasthmatic &

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Published by ianecunar

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Published by: ianecunar on Oct 17, 2009
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08/13/2013

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Brand name:
 
AnsimarGeneric name:
Doxofylline
Drug Classification:
Antiasthmatic & COPD Preparations
Indication:
Bronchial asthma & pulmonary disease w/ spastic bronchial component.
Mechanism of action:
Adrenergic bronchodilators and phosphodiesterase inhibitors bothwork by increasing intracellular level of cyclic-3’,5’- adenosine monophosphate(cAMP); adrenergics by increasing production and phosphodiesterase inhibitors by decreasing breakdown. Increased levels of cAMP produce bronchodilation.Corticosteroids act by decreasing airway inflammation. Anticholinergics(ipratropium) produce brondhodilation by decreasing intracellular levels of cyclic guanosine monophosphate (cGMP). Leukotriene receptor antagonists andmast cell stabilizers decrease the release of substances that can contribute to bronchospasm.
Dosage:
 
Tab
Adult 1 tab bid- tid.
Syr 
Children >12 yr 10 mL once- tid, <12 yrs 6-9mg/kg bid.
Contraindication:
Acute MI, hypotension, lactation
Special Precaution:
Liver disease, CHF, chronic obstructive lung disease, concomitantinfections. Pregnancy.

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